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Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.

TitleGenetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.
Publication TypeJournal Article
Year of Publication2022
AuthorsTaub MA, Conomos MP, Keener R, et al.
Corporate AuthorsNHLBI CARE Network, NHLBI Trans-Omics for Precision Medicine(TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group
JournalCell Genom
Volume2
Issue1
Date Published2022 Jan 12
ISSN2666-979X
Abstract

Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value
DOI10.1016/j.xgen.2021.100084
Alternate JournalCell Genom
PubMed ID35530816
PubMed Central IDPMC9075703
Grant ListR01 HL104135 / HL / NHLBI NIH HHS / United States
R01 HL071250 / HL / NHLBI NIH HHS / United States
R01 NS058700 / NS / NINDS NIH HHS / United States
U01 HL117721 / HL / NHLBI NIH HHS / United States
U10 HL054472 / HL / NHLBI NIH HHS / United States
U01 HL054472 / HL / NHLBI NIH HHS / United States
R01 HL113264 / HL / NHLBI NIH HHS / United States
R01 HL080083 / HL / NHLBI NIH HHS / United States
OT3 HL142478 / HL / NHLBI NIH HHS / United States
UM1 HL098162 / HL / NHLBI NIH HHS / United States
R01 HL112064 / HL / NHLBI NIH HHS / United States
R01 ES021801 / ES / NIEHS NIH HHS / United States
R01 HL095080 / HL / NHLBI NIH HHS / United States
U01 HL072496 / HL / NHLBI NIH HHS / United States
UM1 HL098123 / HL / NHLBI NIH HHS / United States
R01 HL133040 / HL / NHLBI NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
R01 HL087698 / HL / NHLBI NIH HHS / United States
R01 HL046380 / HL / NHLBI NIH HHS / United States
R01 HL092217 / HL / NHLBI NIH HHS / United States
R01 HL121007 / HL / NHLBI NIH HHS / United States
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R01 HL071259 / HL / NHLBI NIH HHS / United States
U01 HL054527 / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
R01 HL069234 / HL / NHLBI NIH HHS / United States
UM1 HG008895 / HG / NHGRI NIH HHS / United States
R01 HL068986 / HL / NHLBI NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
R01 HL087660 / HL / NHLBI NIH HHS / United States
R01 AR048797 / AR / NIAMS NIH HHS / United States
R01 HL092577 / HL / NHLBI NIH HHS / United States
HHSN268200800007C / HL / NHLBI NIH HHS / United States
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R01 HL066216 / HL / NHLBI NIH HHS / United States
U01 HL089897 / HL / NHLBI NIH HHS / United States
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U10 HL064307 / HL / NHLBI NIH HHS / United States
R01 AG058921 / AG / NIA NIH HHS / United States
R01 HL141845 / HL / NHLBI NIH HHS / United States
R01 HL089856 / HL / NHLBI NIH HHS / United States
U10 HL064295 / HL / NHLBI NIH HHS / United States
OT3 HL142481 / HL / NHLBI NIH HHS / United States
U01 HL065962 / HL / NHLBI NIH HHS / United States
U10 HL064288 / HL / NHLBI NIH HHS / United States
U01 HL054464 / HL / NHLBI NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
OT3 HL147154 / HL / NHLBI NIH HHS / United States
U10 HL064287 / HL / NHLBI NIH HHS / United States
R01 HL119443 / HL / NHLBI NIH HHS / United States
R37 HL066289 / HL / NHLBI NIH HHS / United States
U01 HL089856 / HL / NHLBI NIH HHS / United States
R01 HL067348 / HL / NHLBI NIH HHS / United States
R25 GM062459 / GM / NIGMS NIH HHS / United States
R01 HL113326 / HL / NHLBI NIH HHS / United States
R01 HL071051 / HL / NHLBI NIH HHS / United States
U01 HL072524 / HL / NHLBI NIH HHS / United States
P01 ES011627 / ES / NIEHS NIH HHS / United States
HHSN268201200036C / HL / NHLBI NIH HHS / United States
HHSN268201800001C / HL / NHLBI NIH HHS / United States
U10 HL064305 / HL / NHLBI NIH HHS / United States
U01 HL054457 / HL / NHLBI NIH HHS / United States
N01HC95159 / HL / NHLBI NIH HHS / United States
R01 HD074711 / HD / NICHD NIH HHS / United States
R01 HL104608 / HL / NHLBI NIH HHS / United States
RC2 GM092618 / GM / NIGMS NIH HHS / United States
P01 HL045522 / HL / NHLBI NIH HHS / United States
OT3 HL142480 / HL / NHLBI NIH HHS / United States
UM1 HL128761 / HL / NHLBI NIH HHS / United States
U01 HL072518 / HL / NHLBI NIH HHS / United States
P50 GM115305 / GM / NIGMS NIH HHS / United States
U10 HL109164 / HL / NHLBI NIH HHS / United States
HHSN268201500014C / HL / NHLBI NIH HHS / United States
R01 HL133221 / HL / NHLBI NIH HHS / United States
75N92021D00006 / HL / NHLBI NIH HHS / United States
R01 HL080467 / HL / NHLBI NIH HHS / United States
N01HC85082 / HL / NHLBI NIH HHS / United States
R01 HL068959 / HL / NHLBI NIH HHS / United States
U01 HL072507 / HL / NHLBI NIH HHS / United States
R01 DK071891 / DK / NIDDK NIH HHS / United States
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U01 HL054481 / HL / NHLBI NIH HHS / United States
R03 HL154284 / HL / NHLBI NIH HHS / United States
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R01 HL055673 / HL / NHLBI NIH HHS / United States
R01 HL079915 / HL / NHLBI NIH HHS / United States
R01 HL092301 / HL / NHLBI NIH HHS / United States
K01 HL135405 / HL / NHLBI NIH HHS / United States
N01HC85081 / HL / NHLBI NIH HHS / United States
U10 HL064313 / HL / NHLBI NIH HHS / United States