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ARIC: Impact and Findings

A researcher holding a vial of fluidARIC’s many discoveries have increased understanding of the causes of atherosclerosis and cardiovascular disease, advanced cardiovascular disease prevention, and shaped guidelines for treating coronary heart disease, diabetes, stroke, and chronic kidney disease.

ARIC data have been used in nearly 2500 publications, with findings that include:
  • ARIC was the first to sequence a region in the PCSK9 gene on a large population.
    1
    Based on this finding, a medication was developed to help prevent coronary heart disease.
  • Among African Americans, sickle cell trait was associated with increased risk of chronic kidney disease and pulmonary embolism risk.
    2,3
A pencil and a checkbox by the word Hemoglobin
  • New markers of high blood sugar are strongly related to cardiovascular disease risk and using hemoglobin A1c and fasting glucose together can improve diabetes diagnosis.
    4,5
  • Cardiac troponin is a marker of heart muscle damage and BNP is a marker of heart muscle stretch. Both are associated with risk of developing cardiovascular disease.
    6-9
  • Cardiovascular risk factors measured during middle age are associated with risk of developing dementia in older age.
    10
ARIC has also worked on identifying risk factors for other diseases, such as: abdominal aortic aneurysm,
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peripheral artery disease,
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hypertension,
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chronic kidney disease,
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silent stroke detected by MRI,
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retinopathy,
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echocardiographic findings,
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venous thrombosis,
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diabetes,
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cancer,
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and weight gain.
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We look forward to our ongoing partnerships with ARIC’s core investigators and many new researchers in coming years, as the valuable data that ARIC has collected continues to yield new findings and scientific discoveries.

Literature Cited

1. Cohen JC, et al. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006;354(12):1264-72.
2. Naik RP, et al. Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans. JAMA 2014;312(20):2115-25.
3. Folsom AR, et al. Prospective study of sickle cell trait and venous thromboembolism incidence. J Thromb Haemost 2015;13(1):2-9.
4. Selvin E, et al. Glycated hemglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med 2010;362(9):800-11.
5. Selvin E, et al. Prognostic implications of single-sample confirmatory testing for undiagnosed diabetes: A prospective cohort study. Ann Intern Med 2018 Jun 19. doi: 10.7326/M18-0091. [Epub ahead of print]
6. Folsom AR, et al. Troponin T, NT-proBNP, and venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE). Vasc Med 2014;19(1):33-41.
7. Nambi V, et al. Troponin T and N-terminal pro-B-type natriuretic peptide: A biomarker approach to predict heart failure risk: The Atherosclerosis Risk in Communities Study. Clin Chem 2013;59(12):1802-10.
8. Oluleye OW, et al. Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality. Ann Epidemiol 2013;23(2):66-73.
9. Saunders JT, et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation 2011;123(13):1367-76.
10. Gottesman RF, et al. Associations between midlife vascular risk factors and 25-year incident dementia in the Atherosclerosis Risk in Communities (ARIC) cohort. JAMA Neurol 2017;74(10):1246-1254.
11. Tang W, et al. Lifetime risk and risk factors for abdominal aortic aneurysm in a 24-year prospective study: The ARIC Study (Atherosclerosis Risk in Communities). Arterioscler Thromb Vasc Biol 2016;36(12):2468-77.
12. Ogilvie RP, et al. Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr 2017;105(3):651-9.
13. Diez Roux AV, et al. Socioeconomic disadvantage and change in blood pressure associated with aging. Circulation 2002;106(6):703-10.
14. Rebholz CM, et al. Relationship of the American Heart Association’s Impact Goals (Life’s Simple 7) with risk of chronic kidney disease: Results from the Atherosclerosis Risk in Communities (ARIC) cohort study. J Am Heart Assoc 2016;5(4):e003192.
15. Knuiman MW, et al. Association of hemostatic variables with MRI-detected cerebral abnormalities: the Atherosclerosis Risk in Communities Study. Neuroepidemiology 2001;20(2):96-104.
16. Klein R, et al. The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes : the Atherosclerosis Risk in Communities Study. Ophthalmology 2002;109(7):1225-34.
17. Astor BC, et al. Association of kidney function and hemoglobin with left ventricular morphology among African Americans: the Atherosclerosis Risk in Communities (ARIC) study. Am J Kidney Dis 2004;43(5):836-45.
18. Bell EJ, et al. Lifetime risk of venous thromboembolism in two cohort studies. Am J Med 2016;129(3):339.e19-26.
19. Duncan BB, et al. Low-grade systemic inflammation and the development of type 2 diabetes: The Atherosclerosis Risk in Communities Study. Diabetes 2003;52(7):1799-805.
20. Prizment AE, et al. Plasma C-reactive protein, genetic risk score, and risk of common cancers in the Atherosclerosis Risk in Communities study. Cancer Causes Control 2013;24(12):2077-87.
21. Juhaeri, et al. Weight change among self-reported dieters and non-dieters in white and African American men and women. Eur J Epidemiol 2001;17(10):917-23.