Adolescent Medicine Trials Network for HIV/AIDS Interventions Data Harmonization: Rationale and Development of Guidelines.

TitleAdolescent Medicine Trials Network for HIV/AIDS Interventions Data Harmonization: Rationale and Development of Guidelines.
Publication TypePublication
Year of Publication2018
AuthorsMcCumber M, Cain D, LeGrand S, Mayer KH, Murphy DA, Psioda MA, Seña AC, Starks TJ, Hudgens M
JournalJMIR Res Protoc
Volume7
Issue12
Paginatione11207
Date Published2018 Dec 21
ISSN1929-0748
Abstract

<p><b>BACKGROUND: </b>The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) research program aims to defeat the rising HIV epidemic among adolescents and young adults in the United States.</p><p><b>OBJECTIVE: </b>This study aims to optimize cross-study analyses and comparisons of standardized measures (variables) collected in the ATN.</p><p><b>METHODS: </b>Guidelines were developed for harmonizing measures to be collected across ATN studies.</p><p><b>RESULTS: </b>Eight domains were identified for harmonization-Demographics and Socioeconomic Characteristics, Sexual Behavior and Risk, Substance Use and Abuse, HIV-Positive Cascade, HIV-Negative Cascade, Mental Health, Social Support and Isolation, and Pre-exposure Prophylaxis Cascade.</p><p><b>CONCLUSIONS: </b>The collection of selected key measures in a uniform manner across studies facilitates the characterization of participant populations, comparisons between studies, and pooled analysis of data from multiple studies.</p>

DOI10.2196/11207
Alternate JournalJMIR Res Protoc
PubMed ID30578242
PubMed Central IDPMC6320398
Grant ListU24 HD089880 / HD / NICHD NIH HHS / United States
U19 HD089881 / HD / NICHD NIH HHS / United States
U19 HD089886 / HD / NICHD NIH HHS / United States
U19 HD089875 / HD / NICHD NIH HHS / United States
P30 AI050410 / AI / NIAID NIH HHS / United States