Pre-vaccination prevalence of anogenital and oral human papillomavirus in young HIV-infected men who have sex with men

TitlePre-vaccination prevalence of anogenital and oral human papillomavirus in young HIV-infected men who have sex with men
Publication TypePublication
Year of Publication2019
AuthorsKahn JA, Belzer M, Chi X, Lee J, Gaur AH, Mayer K, Martinez J, Futterman DC, Stier EA, Paul ME, Chiao EY, Reirden D, Goldstone SE, Martinez APOrtiz, Cachay ER, Barroso LF, Da Costa M, Wilson CM, Palefsky JM
Corporate AuthorsAIDS Malignancy Consortium and Adolescent Medicine Trials Network for HIV/AIDS Interventions
JournalPapillomavirus Res
Volume7
Pagination52-61
Date Published2019 Jun
ISSN2405-8521
Abstract

The aims of this study were to: 1) determine prevalence of anogenital and oral HPV, 2) determine concordance between HPV at anal, perianal, scrotal/penile, and oral sites; and 3) describe factors associated with anogenital HPV types targeted by the 9-valent vaccine. Data were collected from 2012 to 2015 among men who have sex with men 18-26 years of age enrolled in a vaccine trial (N = 145). Penile/scrotal, perianal, anal, and oral samples were tested for 61 HPV types. Logistic regression was used to identify factors associated with types in the 9-valent vaccine. Participants' mean age was 23.0 years, 55.2% were African-American, and 26.2% were Hispanic; 93% had anal, 40% penile, and 6% oral HPV. Among those with anogenital infection, 18% had HPV16. Concordance was low between anogenital and oral sites. Factors independently associated with a 9-valent vaccine-type HPV were: race (African-American vs. White, OR=2.67, 95% CI=1.11-6.42), current smoking (yes vs. no, OR=2.37, 95% CI=1.03-5.48), and number of recent receptive anal sex partners (2+ vs. 0, OR=3.47, 95% CI=1.16-10.4). Most MSM were not infected with HPV16 or HPV18, suggesting that they may still benefit from HPV vaccination, but anogenital HPV was very common, highlighting the importance of vaccinating men before sexual initiation. CLINICAL TRIAL NUMBER: NCT01209325.

DOI10.1016/j.pvr.2019.01.002
Alternate JournalPapillomavirus Res
PubMed ID30658128
PubMed Central IDPMC6356116
Grant ListP50 CA121974 / CA / NCI NIH HHS / United States
U01 HD040474 / HD / NICHD NIH HHS / United States
U01 HD040533 / HD / NICHD NIH HHS / United States