Changes in Bone Mass After Discontinuation of Pre-Exposure Prophylaxis (PrEP) with Tenofovir Disoproxil Fumarate/Emtricitabine in Young Men Who Have Sex With Men: Extension Phase Results of Adolescent Trials Network Protocols 110 and 113

TitleChanges in Bone Mass After Discontinuation of Pre-Exposure Prophylaxis (PrEP) with Tenofovir Disoproxil Fumarate/Emtricitabine in Young Men Who Have Sex With Men: Extension Phase Results of Adolescent Trials Network Protocols 110 and 113
Publication TypePublication
Year of Publication2019
AuthorsHavens PL, Perumean-Chaney SE, Patki A, Cofield SS, Wilson CM, Liu N, Anderson PL, Landovitz RJ, Kapogiannis BG, Hosek SG, Mulligan K
JournalClin Infect Dis
Date Published2019 Jun 08
ISSN1537-6591
Abstract

HIV-seronegative men who have sex with men aged 15-22 years who lost bone mineral density (BMD) during TDF/FTC PrEP experienced partial or full BMD recovery 48 weeks following PrEP discontinuation, except lumbar spine and whole body BMD Z-scores remained below baseline 48 weeks off PrEP in participants aged 15-19 years.

DOI10.1093/cid/ciz486
Alternate JournalClin. Infect. Dis.
PubMed ID31179503