Title | Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy. |
Publication Type | Publication |
Year of Publication | 2019 |
Authors | Kim-Chang JJ, Wilson L, Chan C, Fischer B, Venturi G, Goodenow MM, Aldrovandi G, Weber TJ, Sleasman JW |
Corporate Authors | Adolescent Medicine Trials Network for HIV/AIDS Interventions |
Journal | AIDS Res Hum Retroviruses |
Volume | 35 |
Issue | 8 |
Pagination | 746-754 |
Date Published | 2019 Aug |
ISSN | 1931-8405 |
Keywords | Adolescent, Alkaline Phosphatase, Anti-HIV Agents, Biomarkers, Bone and Bones, Bone Density, Bone Diseases, Metabolic, Female, HIV Infections, Humans, Lymphocyte Activation, Macrophage Activation, Macrophages, Male, Osteopontin, Osteoprotegerin, Parathyroid Hormone, RANK Ligand, Tenofovir, Young Adult |
Abstract | <p>Both HIV infection and tenofovir disoproxil fumarate (TDF) treatment adversely impact bone metabolism and may lead to osteopenia, which has critical implications for youth with HIV (YWH). This study evaluates changes in the biomarkers of bone metabolism and inflammation among YWH receiving initial treatment with TDF- and non-TDF-containing antiretroviral therapies (ARTs). YWH [ = 23, median age 21 years (range 18-24), 87% male, 61% African American] were assessed for inflammatory and bone metabolism biomarkers at enrollment, after 48 weeks of TDF-containing ART, and 96 weeks of ART without TDF with continued viral suppression. Spearman's rank correlation evaluated biomarker associations. Bone alkaline phosphatase, parathyroid hormone, and osteopontin increased after TDF treatment. All fell after TDF was discontinued. Levels of RANKL and osteoprotegerin did not change throughout the study. There was little correlation between biomarkers of bone metabolism and either macrophage or lymphocyte activation at any time point. Our results establish baseline associations between bone metabolism and immune biomarkers for this population, and find that before CD4 T cell decline chronic inflammation does not perturb biomarkers of bone metabolism among YWH. The adverse effects of TDF on bone health may be marginal for YWH at the early stages of disease.</p> |
DOI | 10.1089/AID.2018.0270 |
Alternate Journal | AIDS Res Hum Retroviruses |
PubMed ID | 31115244 |
PubMed Central ID | PMC6688113 |
Grant List | U01 HD040533 / HD / NICHD NIH HHS / United States T32 AI007062 / AI / NIAID NIH HHS / United States U01 HD040474 / HD / NICHD NIH HHS / United States UL1 RR025780 / RR / NCRR NIH HHS / United States U01 AI068632 / AI / NIAID NIH HHS / United States UL1 TR002535 / TR / NCATS NIH HHS / United States UL1 RR024131 / RR / NCRR NIH HHS / United States U01 DA044571 / DA / NIDA NIH HHS / United States M01 RR010284 / RR / NCRR NIH HHS / United States P30 AI064518 / AI / NIAID NIH HHS / United States UL1 RR024134 / RR / NCRR NIH HHS / United States M01 RR020359 / RR / NCRR NIH HHS / United States |