Higher soluble CD14 levels are associated with lower visuospatial memory performance in Youth with HIV (YWH).

TitleHigher soluble CD14 levels are associated with lower visuospatial memory performance in Youth with HIV (YWH).
Publication TypePublication
Year of Publication2019
AuthorsKim-Chang JJ, Donovan K, Loop MShane, Hong S, Fischer B, Venturi G, Garvie PA, Kohn J, H Rendina J, Woods SP, Goodenow MM, Nichols SL, Sleasman JW
Corporate AuthorsAdolescent Medicine Trials Network for HIV/AIDS Interventions
Date Published2019 Sep 02

<p><b>OBJECTIVE: </b>HIV-associated neurocognitive disorders persist despite early antiretroviral therapy (ART) and optimal viral suppression. We examined the relationship between immunopathogenesis driven by various pathways of immune activation and discrete neurocognitive performance domains in youth with HIV (YWH).</p><p><b>DESIGN: </b>Observational cross-sectional study METHODS:: YWH, ages 20 to 28, enrolled in Adolescent Medicine Trials Network 071/101 were assessed for biomarkers of macrophage, lymphocyte activation and vascular inflammation using ELISA/multiplex assays. Standardized neurocognitive tests were performed, and demographically-adjusted z-scores were combined to form indices of attention, motor, executive function, verbal and visuospatial memory. Cross-sectional analysis of the relationship between 18 plasma inflammatory biomarkers and each neurocognitive domain was performed. Linear regression models were fit for each combination of log-transformed biomarker value and neurocognitive domain score, and were adjusted for demographics, socioeconomic status, substance use, depression, CD4 T cell count, HIV viral load, and ART status.</p><p><b>RESULTS: </b>Study included 128 YWH [mean age 23.8 (SD 1.7) years, 86% men, 68% African American]. Verbal and visuospatial memory domains were most significantly impaired in the cohort (z = -1.59 and -1.0, respectively). Higher sCD14 was associated with impaired visuospatial memory, which remained robust after adjusting for other biomarkers, demographics, and HIV-associated covariates. Among biomarkers of vascular inflammation, sICAM-1 was negatively associated with verbal memory and attention, while sVCAM-1 was positively associated with executive function and visuospatial memory. Specific neurocognitive domains were not associated with sCD163, LPS, or CCL2 levels.</p><p><b>CONCLUSIONS: </b>Impaired visuospatial memory in YWH is associated with immune activation, as reflected by higher sCD14.</p>

Alternate JournalAIDS
PubMed ID31483376
Grant ListU24 HD089880 / HD / NICHD NIH HHS / United States
U01 HD040533 / HD / NICHD NIH HHS / United States
T32 AI007062 / AI / NIAID NIH HHS / United States
U01 HD040474 / HD / NICHD NIH HHS / United States
U01 AI068632 / AI / NIAID NIH HHS / United States
P30 AI064518 / AI / NIAID NIH HHS / United States