Improving the Youth HIV Prevention and Care Cascades: Innovative Designs in the Adolescent Trials Network for HIV/AIDS Interventions.

TitleImproving the Youth HIV Prevention and Care Cascades: Innovative Designs in the Adolescent Trials Network for HIV/AIDS Interventions.
Publication TypePublication
Year of Publication2019
AuthorsNaar S, Hudgens MG, Brookmeyer R, Carcone AIdalski, Chapman J, Chowdhury S, Ciaranello A, W Comulada S, Ghosh S, Horvath KJ, Ingram LD, LeGrand S, Reback CJ, Simpson K, Stanton B, Starks T, Swendeman D
JournalAIDS Patient Care STDS
Volume33
Issue9
Pagination388-398
Date Published2019 09
ISSN1557-7449
KeywordsAcquired Immunodeficiency Syndrome, Adolescent, Adolescent Behavior, Antiretroviral Therapy, Highly Active, HIV Infections, Humans, Pre-Exposure Prophylaxis, Young Adult
Abstract

<p>Dramatic decreases in HIV transmission are achievable with currently available biomedical and behavioral interventions, including antiretroviral therapy and pre-exposure prophylaxis. However, such decreases have not yet been realized among adolescents and young adults. The Adolescent Medicine Trials Network (ATN) for HIV/AIDS interventions is dedicated to research addressing the needs of youth at high risk for HIV acquisition as well as youth living with HIV. This article provides an overview of an array of efficient and effective designs across the translational spectrum that are utilized within the ATN. These designs maximize methodological rigor and real-world applicability of findings while minimizing resource use. Implementation science and cost-effectiveness methods are included. Utilizing protocol examples, we demonstrate the feasibility of such designs to balance rigor and relevance to shorten the science-to-practice gap and improve the youth HIV prevention and care continua.</p>

DOI10.1089/apc.2019.0095
Alternate JournalAIDS Patient Care STDS
PubMed ID31517525
PubMed Central IDPMC6745528
Grant ListU24 HD089880 / HD / NICHD NIH HHS / United States
U19 HD089881 / HD / NICHD NIH HHS / United States
P30 MH058107 / MH / NIMH NIH HHS / United States
P30 AI050410 / AI / NIAID NIH HHS / United States
U19 HD089886 / HD / NICHD NIH HHS / United States
U19 HD089875 / HD / NICHD NIH HHS / United States