Feasibility of Ethyl Glucuronide Nail Testing Biomarker for Alcohol Use Among Youth Living With HIV.

TitleFeasibility of Ethyl Glucuronide Nail Testing Biomarker for Alcohol Use Among Youth Living With HIV.
Publication TypePublication
Year of Publication2021
AuthorsBudhwani H, Dinaj V, Jacques-Tiura AJ, Pennar AL, Naar S
JournalJ Adolesc Health
Volume69
Issue2
Pagination346-348
Date Published2021 08
ISSN1879-1972
KeywordsAdolescent, Alcohol Drinking, Biomarkers, Feasibility Studies, Glucuronates, HIV Infections, Humans, Substance Abuse Detection
Abstract

<p><b>PURPOSE: </b>We assessed the feasibility of the ethyl glucuronide biomarker (EtG) through nail sampling to measure alcohol use among youth living with HIV in the United States (YLWH, N = 183); we also evaluated concordance between this EtG biomarker and self-reported measures of alcohol use, specifically, the Alcohol Timeline Followback (TFLB) and Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST).</p><p><b>METHODS: </b>EtG, TFLB, and ASSIST were collected at 4 points over 1 year. At baseline and 52 weeks, 78.1% and 70.1%, respectively, provided a valid (full or partial) sample.</p><p><b>RESULTS: </b>At 16 weeks, EtG was associated with ASSIST (r = .25, p < .05). At 28 weeks and 52 weeks, TFLB and ASSIST were correlated with EtG (at 28 weeks r = .23, p < .05 and r = .41, p < .01, respectively; at 52 weeks r = .34, p < .01 and r = .25, p < .05, respectively).</p><p><b>CONCLUSIONS: </b>We found that nail-based EtG biomarker was feasible to measure alcohol use among YLWH; we also found concordance between EtG, TLFB, and ASSIST, supporting ongoing use of self-reported alcohol use measures with YLWH.</p>

DOI10.1016/j.jadohealth.2020.12.134
Alternate JournalJ Adolesc Health
PubMed ID33602615
PubMed Central IDPMC8316253
Grant ListK01 AA024500 / AA / NIAAA NIH HHS / United States
K01 MH116737 / MH / NIMH NIH HHS / United States
R01 AA022891 / AA / NIAAA NIH HHS / United States
U19 HD089875 / HD / NICHD NIH HHS / United States