Design and analysis considerations for a sequentially randomized HIV prevention trial

TitleDesign and analysis considerations for a sequentially randomized HIV prevention trial
Publication TypePublication
Year of Publication2020
AuthorsBenkeser D, Horvath K, Reback CJ, Rusow J, Hudgens M
JournalStat Biosci
Volume12
Issue3
Pagination446-467
Date Published2020 Dec
ISSN1867-1764
Abstract

<p>TechStep is a randomized trial of a mobile health interventions targeted towards transgender adolescents. The interventions include a short message system, a mobile-optimized web application, and electronic counseling. The primary outcomes are self-reported sexual risk behaviors and uptake of HIV preventing medication. In order that we may evaluate the efficacy of several different combinations of interventions, the trial has a sequentially randomized design. We use a causal framework to formalize the estimands of the primary and key secondary analyses of the TechStep trial data. Targeted minimum loss-based estimators of these quantities are described and studied in simulation.</p>

DOI10.1007/s12561-020-09274-3
Alternate JournalStat Biosci
PubMed ID33767798
PubMed Central IDPMC7986973
Grant ListP30 MH058107 / MH / NIMH NIH HHS / United States
R01 AI029168 / AI / NIAID NIH HHS / United States
U19 HD089881 / HD / NICHD NIH HHS / United States
U24 HD089880 / HD / NICHD NIH HHS / United States