Title | Design and analysis considerations for a sequentially randomized HIV prevention trial. |
Publication Type | Publication |
Year of Publication | 2020 |
Authors | Benkeser D, Horvath K, Reback CJ, Rusow J, Hudgens M |
Journal | Stat Biosci |
Volume | 12 |
Issue | 3 |
Pagination | 446-467 |
Date Published | 2020 Dec |
ISSN | 1867-1764 |
Abstract | <p>TechStep is a randomized trial of a mobile health interventions targeted towards transgender adolescents. The interventions include a short message system, a mobile-optimized web application, and electronic counseling. The primary outcomes are self-reported sexual risk behaviors and uptake of HIV preventing medication. In order that we may evaluate the efficacy of several different combinations of interventions, the trial has a sequentially randomized design. We use a causal framework to formalize the estimands of the primary and key secondary analyses of the TechStep trial data. Targeted minimum loss-based estimators of these quantities are described and studied in simulation.</p> |
DOI | 10.1007/s12561-020-09274-3 |
Alternate Journal | Stat Biosci |
PubMed ID | 33767798 |
PubMed Central ID | PMC7986973 |
Grant List | U24 HD089880 / HD / NICHD NIH HHS / United States U19 HD089881 / HD / NICHD NIH HHS / United States R37 AI029168 / AI / NIAID NIH HHS / United States R01 AI029168 / AI / NIAID NIH HHS / United States P30 MH058107 / MH / NIMH NIH HHS / United States |