Correlates of High HIV Viral Load and Antiretroviral Therapy Adherence Among Viremic Youth in the United States Enrolled in an Adherence Improvement Intervention

TitleCorrelates of High HIV Viral Load and Antiretroviral Therapy Adherence Among Viremic Youth in the United States Enrolled in an Adherence Improvement Intervention
Publication TypePublication
Year of Publication2021
AuthorsK Amico R, Crawford J, Ubong I, Lindsey JC, Gaur AH, Horvath K, Goolsby R, Johnson MMueller, Dallas R, Heckman B, Filipowicz T, Polier M, Rupp BM, Hudgens M
JournalAIDS Patient Care STDS
Volume35
Issue5
Pagination145-157
Date Published2021 05
ISSN1557-7449
KeywordsAdolescent, Adult, Anti-HIV Agents, HIV Infections, Humans, Medication Adherence, United States, Viral Load, Viremia, Young Adult
Abstract

<p>A sizable portion of youth (ages 13-24) living with HIV in the United States have unsuppressed viral load. The AIDS Interventions (ATN) 152 study [evaluating the Triggered Escalating Real-Time Adherence (TERA) intervention] baseline data were examined to identify correlates of high viremia (>5000 copies/mL) and self-reported adherence, which can help in planning of differentiated services for viremic youth. Depression, HIV-stigma, and cannabis use were common in this sample of 87 youth. Almost half (48%) had high viremia, which associated with enacted stigma, moderate- to high-risk alcohol use, mental health diagnosis, and age ≥21. Self-reported adherence was related to viral load and associated with mental and physical health functioning, depression, social support, self-confident decision-making, total and internalized stigma, adherence motivation, and report of a missed a care visit in the past 6 months. Mental health emerged as a common correlate of viral load and adherence. Clinical Trial Registration number: NCT03292432.</p>

DOI10.1089/apc.2021.0005
Alternate JournalAIDS Patient Care STDS
PubMed ID33960843
PubMed Central IDPMC8106249
Grant ListU24 HD089880 / HD / NICHD NIH HHS / United States