Incidence of sexually transmitted infections in HIV-infected and HIV-uninfected adolescents in the USA.

TitleIncidence of sexually transmitted infections in HIV-infected and HIV-uninfected adolescents in the USA.
Publication TypePublication
Year of Publication2013
AuthorsMullins TLK, Rudy BJ, Wilson CM, Sucharew H, Kahn JA
JournalInt J STD AIDS
Date Published2013 Feb
KeywordsAdolescent, Child, Chlamydia Infections, Female, Gonorrhea, HIV Infections, HIV Seronegativity, Humans, Incidence, Interviews as Topic, Longitudinal Studies, Male, Multivariate Analysis, Proportional Hazards Models, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Trichomonas Infections, United States

<p>Little is known about the incidence of bacterial sexually transmitted infections (STIs) among HIV-infected versus HIV-uninfected adolescents. This secondary analysis of a national, multisite study included adolescents aged 12-18 years who were behaviourally HIV-infected (n = 346) or HIV-uninfected but at-risk (n = 182). Incidence rates of bacterial STIs (gonorrhoea, chlamydia [CT] and trichomonas [TV; women]) were calculated using Poisson modelling. Factors associated with incident STIs were explored using Cox proportional hazards modelling. HIV-infected versus HIV-uninfected women had higher TV incidence (1.3 versus 0.6/100 person-months; P = 0.002). HIV-uninfected versus HIV-infected women had higher CT incidence (1.6 versus 1.1/100 person-months; P = 0.04). Among women, demographic, behavioural and HIV-related factors were associated with incident STIs. Among men, there were no differences in incident STIs. In this first analysis comparing STI incidence between HIV-infected and HIV-uninfected adolescents, bacterial STI incidence among women significantly differed by HIV status, and factors associated with incident STIs varied by STI and HIV status.</p>

Alternate JournalInt J STD AIDS
PubMed ID23467290
PubMed Central IDPMC4327832
Grant ListU01 HD032842 / HD / NICHD NIH HHS / United States