Vitamin D status in adolescents and young adults with HIV infection.

TitleVitamin D status in adolescents and young adults with HIV infection.
Publication TypePublication
Year of Publication2006
AuthorsStephensen CB, Marquis GS, Kruzich LA, Douglas SD, Aldrovandi GM, Wilson CM
JournalAm J Clin Nutr
Date Published2006 May
KeywordsAdolescent, Adult, African Continental Ancestry Group, Calcifediol, Diet, Dietary Supplements, Female, Hispanic Americans, HIV Infections, Humans, Male, Nutritional Status, Pregnancy, Regression Analysis, Seasons, Vitamin D, Vitamin D Deficiency

<p><b>BACKGROUND: </b>Vitamin D status affects immune function and thus may affect the progress of HIV infection.</p><p><b>OBJECTIVES: </b>Our goals were to assess vitamin D intake and status in subjects with HIV infection and in matched control subjects and to determine whether HIV infection was associated with vitamin D insufficiency.</p><p><b>DESIGN: </b>Plasma 25-hydroxyvitamin D [25(OH)D] concentrations and vitamin D intake were measured in a cross-sectional study of members of the Reaching for Excellence in Adolescent Health (REACH) cohort.</p><p><b>RESULTS: </b>The subjects were aged 14-23 y; 74% were female, and 72% were black. Mean (+/-SE) vitamin D intake from food was 30% greater (P = 0.023) in HIV-positive subjects (295 +/- 18 IU/d; n = 237) than in HIV-negative subjects (227 +/- 26 IU/d; n = 121). The prevalence of vitamin D supplement use was 29% (104 of 358 subjects) and did not differ significantly by HIV status (P = 0.87). Mean plasma 25(OH)D did not differ significantly (P = 0.62) between the HIV-positive (20.3 +/- 1.1 nmol/L; n = 238) and HIV-negative (19.3 +/- 1.7 nmol/L; n = 121) subjects, nor was HIV status a significant predictor of plasma 25(OH)D when multiple regression analysis was used to adjust for other variables. The prevalence of vitamin D insufficiency [plasma 25(OH)D < or = 37.5 nmol/L] in the subjects was 87% (312 of 359 subjects).</p><p><b>CONCLUSIONS: </b>HIV infection did not influence vitamin D status. The prevalence of vitamin D insufficiency in both HIV-positive and HIV-negative REACH subjects was high, perhaps because these disadvantaged, largely urban youth have limited sun exposure.</p>

Alternate JournalAm J Clin Nutr
PubMed ID16685057
Grant ListU01 HD040533 / HD / NICHD NIH HHS / United States
U01-HD32830 / HD / NICHD NIH HHS / United States
U01 HD040474 / HD / NICHD NIH HHS / United States
P60 MD00222-01 / MD / NIMHD NIH HHS / United States
R01 AI46183 / AI / NIAID NIH HHS / United States