Vitamin D status in adolescents and young adults with HIV infection.

TitleVitamin D status in adolescents and young adults with HIV infection.
Publication TypePublication
Year of Publication2006
AuthorsStephensen CB, Marquis GS, Kruzich LA, Douglas SD, Aldrovandi GM, Wilson CM
JournalAm J Clin Nutr
Date Published2006 May
KeywordsAdolescent, Adult, Black People, Calcifediol, Diet, Dietary Supplements, Female, Hispanic or Latino, HIV Infections, Humans, Male, Nutritional Status, Pregnancy, Regression Analysis, Seasons, Vitamin D, Vitamin D Deficiency

<p><b>BACKGROUND: </b>Vitamin D status affects immune function and thus may affect the progress of HIV infection.</p><p><b>OBJECTIVES: </b>Our goals were to assess vitamin D intake and status in subjects with HIV infection and in matched control subjects and to determine whether HIV infection was associated with vitamin D insufficiency.</p><p><b>DESIGN: </b>Plasma 25-hydroxyvitamin D [25(OH)D] concentrations and vitamin D intake were measured in a cross-sectional study of members of the Reaching for Excellence in Adolescent Health (REACH) cohort.</p><p><b>RESULTS: </b>The subjects were aged 14-23 y; 74% were female, and 72% were black. Mean (+/-SE) vitamin D intake from food was 30% greater (P = 0.023) in HIV-positive subjects (295 +/- 18 IU/d; n = 237) than in HIV-negative subjects (227 +/- 26 IU/d; n = 121). The prevalence of vitamin D supplement use was 29% (104 of 358 subjects) and did not differ significantly by HIV status (P = 0.87). Mean plasma 25(OH)D did not differ significantly (P = 0.62) between the HIV-positive (20.3 +/- 1.1 nmol/L; n = 238) and HIV-negative (19.3 +/- 1.7 nmol/L; n = 121) subjects, nor was HIV status a significant predictor of plasma 25(OH)D when multiple regression analysis was used to adjust for other variables. The prevalence of vitamin D insufficiency [plasma 25(OH)D < or = 37.5 nmol/L] in the subjects was 87% (312 of 359 subjects).</p><p><b>CONCLUSIONS: </b>HIV infection did not influence vitamin D status. The prevalence of vitamin D insufficiency in both HIV-positive and HIV-negative REACH subjects was high, perhaps because these disadvantaged, largely urban youth have limited sun exposure.</p>

Alternate JournalAm J Clin Nutr
PubMed ID16685057
Grant ListU01 HD040474 / HD / NICHD NIH HHS / United States
P60 MD00222-01 / MD / NIMHD NIH HHS / United States
R01 AI46183 / AI / NIAID NIH HHS / United States
U01 HD040533 / HD / NICHD NIH HHS / United States
U01-HD32830 / HD / NICHD NIH HHS / United States