Prevalence of primary HIV-1 drug resistance among recently infected adolescents: a multicenter adolescent medicine trials network for HIV/AIDS interventions study.

TitlePrevalence of primary HIV-1 drug resistance among recently infected adolescents: a multicenter adolescent medicine trials network for HIV/AIDS interventions study.
Publication TypePublication
Year of Publication2006
AuthorsViani RM, Peralta L, Aldrovandi G, Kapogiannis BG, Mitchell R, Spector SA, Lie YS, Weidler JM, Bates MP, Liu N, Wilson CM
Corporate AuthorsAdolescent Medicine Trials Network for HIV/AIDS Interventions
JournalJ Infect Dis
Volume194
Issue11
Pagination1505-9
Date Published2006 Dec 01
ISSN0022-1899
KeywordsAdolescent, Adult, Amino Acid Substitution, Anti-HIV Agents, Child, Drug Resistance, Viral, Female, HIV Infections, HIV Protease, HIV Reverse Transcriptase, HIV-1, Humans, Male, Mutation
Abstract

This study examined the prevalence of primary human immunodeficiency type 1 (HIV-1) drug resistance among recently infected youth in the United States. Of the 55 subjects studied, major mutations conferring HIV drug resistance were present in 10 (18%). Eight (15%) had nonnucleoside reverse-transcriptase inhibitor (NNRTI) mutations, with the majority (6) having the K103N mutation; 2 (4%) had nucleoside reverse-transcriptase inhibitor (NRTI) mutations; and 2 (4%) had protease inhibitor (PI) mutations. Phenotypic drug resistance was present in 12 (22%) subjects: 10 (18%) for NNRTIs, 2 (4%) for NRTIs, and 3 (5.5%) for PIs. The prevalence of primary HIV-1 drug resistance, particularly to NNRTIs, in this group of recently infected youth was high.

DOI10.1086/508749
Alternate JournalJ. Infect. Dis.
PubMed ID17083034
Grant ListU01 HD040474 / HD / NICHD NIH HHS / United States
U01 HD040533 / HD / NICHD NIH HHS / United States