Title | Prevalence of primary HIV-1 drug resistance among recently infected adolescents: a multicenter adolescent medicine trials network for HIV/AIDS interventions study. |
Publication Type | Publication |
Year of Publication | 2006 |
Authors | Viani RM, Peralta L, Aldrovandi G, Kapogiannis BG, Mitchell R, Spector SA, Lie YS, Weidler JM, Bates MP, Liu N, Wilson CM |
Corporate Authors | Adolescent Medicine Trials Network for HIV/AIDS Interventions |
Journal | J Infect Dis |
Volume | 194 |
Issue | 11 |
Pagination | 1505-9 |
Date Published | 2006 Dec 01 |
ISSN | 0022-1899 |
Keywords | Adolescent, Adult, Amino Acid Substitution, Anti-HIV Agents, Child, Drug Resistance, Viral, Female, HIV Infections, HIV Protease, HIV Reverse Transcriptase, HIV-1, Humans, Male, Mutation |
Abstract | <p>This study examined the prevalence of primary human immunodeficiency type 1 (HIV-1) drug resistance among recently infected youth in the United States. Of the 55 subjects studied, major mutations conferring HIV drug resistance were present in 10 (18%). Eight (15%) had nonnucleoside reverse-transcriptase inhibitor (NNRTI) mutations, with the majority (6) having the K103N mutation; 2 (4%) had nucleoside reverse-transcriptase inhibitor (NRTI) mutations; and 2 (4%) had protease inhibitor (PI) mutations. Phenotypic drug resistance was present in 12 (22%) subjects: 10 (18%) for NNRTIs, 2 (4%) for NRTIs, and 3 (5.5%) for PIs. The prevalence of primary HIV-1 drug resistance, particularly to NNRTIs, in this group of recently infected youth was high.</p> |
DOI | 10.1086/508749 |
Alternate Journal | J Infect Dis |
PubMed ID | 17083034 |
Grant List | U01 HD040474 / HD / NICHD NIH HHS / United States U01 HD040533 / HD / NICHD NIH HHS / United States |