Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination.

TitleImpaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination.
Publication TypePublication
Year of Publication2010
AuthorsMehta N, Cunningham CK, Flynn P, Pepe J, Obaro S, Kapogiannis BG, Bethel J, Luzuriaga K
Corporate AuthorsAdolescent Trials Network for HIV/AIDS Interventions
JournalVaccine
Volume28
Issue21
Pagination3672-8
Date Published2010 May 07
ISSN1873-2518
KeywordsAdolescent, B-Lymphocytes, Cell Proliferation, Female, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B Vaccines, HIV Infections, Humans, Immunologic Memory, Longitudinal Studies, Male, Young Adult
Abstract

<p>Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.</p>

DOI10.1016/j.vaccine.2010.03.022
Alternate JournalVaccine
PubMed ID20356567
PubMed Central IDPMC2862082
Grant ListP30 AI042845-129006 / AI / NIAID NIH HHS / United States
U01 HD 040533 / HD / NICHD NIH HHS / United States
K24-HD001489 / HD / NICHD NIH HHS / United States
M01RR00083-42 / RR / NCRR NIH HHS / United States
5 U01 AI068632-02 / AI / NIAID NIH HHS / United States
U01 HD040533 / HD / NICHD NIH HHS / United States
U01 HD 040474 / HD / NICHD NIH HHS / United States
U01 HD040474 / HD / NICHD NIH HHS / United States
M01 RR020359-05S1 / RR / NCRR NIH HHS / United States
U01 AI068632 / AI / NIAID NIH HHS / United States
P30 AI064518-04 / AI / NIAID NIH HHS / United States
P30 AI042845 / AI / NIAID NIH HHS / United States
U54 HD061221 / HD / NICHD NIH HHS / United States
K24 HD001489-10 / HD / NICHD NIH HHS / United States
R01 AI032391 / AI / NIAID NIH HHS / United States
M01 RR001271 / RR / NCRR NIH HHS / United States
U01 HD040474-09 / HD / NICHD NIH HHS / United States
U01 HD040533-01 / HD / NICHD NIH HHS / United States
M01RR01271 / RR / NCRR NIH HHS / United States
R01-AI032391 / AI / NIAID NIH HHS / United States
M01 RR001271-24 / RR / NCRR NIH HHS / United States
P30-AI042845 / AI / NIAID NIH HHS / United States
M01RR020359 / RR / NCRR NIH HHS / United States
P30 AI064518 / AI / NIAID NIH HHS / United States
M01 RR000083-42 / RR / NCRR NIH HHS / United States
R01 AI032391-17 / AI / NIAID NIH HHS / United States
M01 RR000083 / RR / NCRR NIH HHS / United States
K24 HD001489 / HD / NICHD NIH HHS / United States
M01 RR020359 / RR / NCRR NIH HHS / United States