Title | Assessment of biomarkers of cardiovascular risk among HIV type 1-infected adolescents: role of soluble vascular cell adhesion molecule as an early indicator of endothelial inflammation. |
Publication Type | Publication |
Year of Publication | 2013 |
Authors | Syed SS, Balluz RS, Kabagambe EK, Meyer WA, Lukas S, Wilson CM, Kapogiannis BG, Nachman SA, Sleasman JW |
Journal | AIDS Res Hum Retroviruses |
Volume | 29 |
Issue | 3 |
Pagination | 493-500 |
Date Published | 2013 Mar |
ISSN | 1931-8405 |
Keywords | Adolescent, Biomarkers, Cardiovascular Diseases, Cohort Studies, Endothelium, Vascular, Female, HIV Infections, HIV-1, Humans, Longitudinal Studies, Male, Vascular Cell Adhesion Molecule-1 |
Abstract | <p>Cardiovascular disease (CVD) biomarkers were examined in a cohort of HIV-infected and HIV-uninfected adolescents who participated in Adolescent Trials Network study 083 utilizing samples from the Reaching for Excellence in Adolescent Care cohort, a longitudinal study of youth infected through adult risk behavior. Nonfasting blood samples from 97 HIV-infected and 81 HIV-uninfected adolescents infected by adult risk behaviors were analyzed for total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), triglycerides, apolipoprotein A-I, high-sensitivity C-reactive protein (hsCRP), soluble vascular adhesion molecule-1 (sVCAM-1), myeloperoxidase, and neopterin at baseline and 18 months later. Results were analyzed using ANOVA, Wilcoxon signed-rank, and paired t tests. Among infected subjects 67 received antiretroviral therapy and 30 were treatment naive. The HIV-infected and HIV-uninfected subjects were similar in gender, ethnicity, and cardiovascular risk factors such as smoking and obesity. In all groups lipid parameters were within accepted guidelines for cardiovascular risk. Among HIV-infected youth on antiretroviral therapy (ART), HDL and apoprotein A-I were significantly lower when compared to uninfected youth. hsCRP was not elevated and thus not predictive for risk in any group. sVCAM-1 levels were significantly elevated in both HIV-infected groups: 1,435 ng/ml and 1,492 ng/ml in untreated and treated subjects, respectively, and 1,064 ng/ml in the uninfected group (p<0.0001). Across all groups neopterin correlated with sVCAM at 18 months (Spearman correlation coefficient 0.58, p<0.0001). Only 9% of ART-treated subjects fully suppressed virus. Lipid profiles and hsCRP, traditional markers of cardiovascular disease, are not abnormal among HIV-infected youth but elevated sVCAM may be an early marker of atherosclerosis.</p> |
DOI | 10.1089/AID.2012.0086 |
Alternate Journal | AIDS Res Hum Retroviruses |
PubMed ID | 23062187 |
PubMed Central ID | PMC3581064 |
Grant List | U01 HD040533 / HD / NICHD NIH HHS / United States U01 HD040474 / HD / NICHD NIH HHS / United States R01 DA031017 / DA / NIDA NIH HHS / United States 5 U01HD40533 / HD / NICHD NIH HHS / United States R01 AI47723 / AI / NIAID NIH HHS / United States 5 U01HD40474 / HD / NICHD NIH HHS / United States 5 U01 HD32842 / HD / NICHD NIH HHS / United States |