Motivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment.

TitleMotivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment.
Publication TypePublication
Year of Publication2013
AuthorsNaar-King S, Outlaw AY, Sarr M, Parsons JT, Belzer M, MacDonell K, Tanney M, Ondersma SJ
Corporate AuthorsAdolescent Medicine Network for HIV/AIDS Interventions
JournalJ Pediatr Psychol
Volume38
Issue6
Pagination638-48
Date Published2013 Jul
ISSN1465-735X
KeywordsAdolescent, Anti-Retroviral Agents, Female, HIV Infections, Humans, Male, Medication Adherence, Motivation, Patient Satisfaction, Pilot Projects, Treatment Outcome, Viral Load, Young Adult
Abstract

<p><b>OBJECTIVE: </b>To pilot test a two-session computer-delivered motivational intervention to facilitate adherence among youth with HIV newly prescribed antiretroviral treatment (ART).</p><p><b>METHODS: </b>Youth (N = 76) newly prescribed ART were recruited from 8 sites, and were randomized to the intervention or an active nutrition and physical activity control. Primary outcomes were HIV-1 viral load at baseline, 3 months, and 6 months, and self-reported adherence at 3 and 6 months.</p><p><b>RESULTS: </b>Satisfaction ratings were high. Effect sizes suggested that the intervention group showed a greater drop than controls in viral load from baseline to 6 months (Cohen's d = 0.39 at 3 months; d = 0.19 at 6 months), and had greater percent undetectable by 6 months (d = 0.28). Effects sizes were medium to large for 7-day and weekend adherence.</p><p><b>CONCLUSIONS: </b>A brief computer-delivered motivational intervention showed promise for youth starting ART and is ready to be tested in a full-scale clinical trial.</p>

DOI10.1093/jpepsy/jss132
Alternate JournalJ Pediatr Psychol
PubMed ID23359664
PubMed Central IDPMC3701125
Grant ListU01 HD040533 / HD / NICHD NIH HHS / United States
U01 HD 040474 / HD / NICHD NIH HHS / United States
U01 HD040474 / HD / NICHD NIH HHS / United States
U01 HD040481 / HD / NICHD NIH HHS / United States
U01-HD040533 / HD / NICHD NIH HHS / United States