Title | Motivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment. |
Publication Type | Publication |
Year of Publication | 2013 |
Authors | Naar-King S, Outlaw AY, Sarr M, Parsons JT, Belzer M, MacDonell K, Tanney M, Ondersma SJ |
Corporate Authors | Adolescent Medicine Network for HIV/AIDS Interventions |
Journal | J Pediatr Psychol |
Volume | 38 |
Issue | 6 |
Pagination | 638-48 |
Date Published | 2013 Jul |
ISSN | 1465-735X |
Keywords | Adolescent, Anti-Retroviral Agents, Female, HIV Infections, Humans, Male, Medication Adherence, Motivation, Patient Satisfaction, Pilot Projects, Treatment Outcome, Viral Load, Young Adult |
Abstract | <p><b>OBJECTIVE: </b>To pilot test a two-session computer-delivered motivational intervention to facilitate adherence among youth with HIV newly prescribed antiretroviral treatment (ART).</p><p><b>METHODS: </b>Youth (N = 76) newly prescribed ART were recruited from 8 sites, and were randomized to the intervention or an active nutrition and physical activity control. Primary outcomes were HIV-1 viral load at baseline, 3 months, and 6 months, and self-reported adherence at 3 and 6 months.</p><p><b>RESULTS: </b>Satisfaction ratings were high. Effect sizes suggested that the intervention group showed a greater drop than controls in viral load from baseline to 6 months (Cohen's d = 0.39 at 3 months; d = 0.19 at 6 months), and had greater percent undetectable by 6 months (d = 0.28). Effects sizes were medium to large for 7-day and weekend adherence.</p><p><b>CONCLUSIONS: </b>A brief computer-delivered motivational intervention showed promise for youth starting ART and is ready to be tested in a full-scale clinical trial.</p> |
DOI | 10.1093/jpepsy/jss132 |
Alternate Journal | J Pediatr Psychol |
PubMed ID | 23359664 |
PubMed Central ID | PMC3701125 |
Grant List | U01 HD040474 / HD / NICHD NIH HHS / United States U01 HD040481 / HD / NICHD NIH HHS / United States U01-HD040533 / HD / NICHD NIH HHS / United States U01 HD040533 / HD / NICHD NIH HHS / United States U01 HD 040474 / HD / NICHD NIH HHS / United States |