Correlation between use of antiretroviral adherence devices by HIV-infected youth and plasma HIV RNA and self-reported adherence.

TitleCorrelation between use of antiretroviral adherence devices by HIV-infected youth and plasma HIV RNA and self-reported adherence.
Publication TypePublication
Year of Publication2015
AuthorsSaberi P, Mayer K, Vittinghoff E, Naar-King S
Corporate AuthorsAdolescent Medicine Trials Network for HIV/AIDS Interventions
JournalAIDS Behav
Volume19
Issue1
Pagination93-103
Date Published2015 Jan
ISSN1573-3254
KeywordsAdolescent, Adolescent Behavior, Anti-Retroviral Agents, CD4 Lymphocyte Count, Child, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, HIV Infections, Humans, Male, Medication Adherence, Medication Systems, Reminder Systems, Self Administration, Self Report, Viral Load
Abstract

<p>Our objective was to investigate antiretroviral adherence device use by HIV-infected youth and assess associations of device use with viral suppression and self-reported adherence. This cross-sectional, multisite, clinic-based study included data from 1,317 HIV-infected individuals 12-24 years of age that were prescribed antiretroviral therapy. Mean adherence in the past 7 days was 86.1 % and 50.5 % had an undetectable HIV RNA. Pillbox was the most commonly endorsed device. No specific device was independently associated with higher odds of 100 % adherence. Paradoxically, having an undetectable HIV RNA was inversely associated with use of adherence devices (OR 0.80; p = 0.04); however, among those with <100 % adherence, higher adherence was associated with use of one or more adherence devices (coefficient = 7.32; p = 0.003). Our data suggest that adolescents who experienced virologic failure often used adherence devices which may not have been sufficiently effective in optimizing adherence. Therefore, other tailored adherence-enhancing methods need to be considered to maximize virologic suppression and decrease drug resistance and HIV transmission.</p>

DOI10.1007/s10461-014-0806-z
Alternate JournalAIDS Behav
PubMed ID24879628
PubMed Central IDPMC4250439
Grant ListU01 HD 040533 / HD / NICHD NIH HHS / United States
U01 HD040533 / HD / NICHD NIH HHS / United States
U01 HD 040474 / HD / NICHD NIH HHS / United States
U01 HD040474 / HD / NICHD NIH HHS / United States
UL1 TR001082 / TR / NCATS NIH HHS / United States
K23 MH097649 / MH / NIMH NIH HHS / United States
K23MH097649 / MH / NIMH NIH HHS / United States