Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021.

TitleBrief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021.
Publication TypePublication
Year of Publication2016
AuthorsRuan A, Tobin NH, Mulligan K, Rollie A, Li F, Sleasman J, Aldrovandi GM
JournalJ Acquir Immune Defic Syndr
Volume72
Issue4
Pagination372-5
Date Published2016 08 01
ISSN1944-7884
KeywordsAbsorptiometry, Photon, Adolescent, Adult, Antiretroviral Therapy, Highly Active, Bone Density, Bone Diseases, Metabolic, Cross-Sectional Studies, Female, HIV Infections, Humans, Macrophage Activation, Male, Osteoporosis, Puerto Rico, Sex Factors, Spine, United States, Young Adult
Abstract

<p>Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than females. Of 11 biomarkers assessed by sex and HIV-status, HIV-infected males had increased levels of soluble CD14 which inversely correlated with bone mineral content and bone mineral density measures, suggesting macrophage activation as a possible mechanism of differential bone loss.</p>

DOI10.1097/QAI.0000000000000953
Alternate JournalJ. Acquir. Immune Defic. Syndr.
PubMed ID26885808
PubMed Central IDPMC4925249
Grant ListU01 HD040533 / HD / NICHD NIH HHS / United States
U01 HD040474 / HD / NICHD NIH HHS / United States
UL1 RR024131 / RR / NCRR NIH HHS / United States
M01 RR000071 / RR / NCRR NIH HHS / United States
M01 RR001271 / RR / NCRR NIH HHS / United States
M01 RR000043 / RR / NCRR NIH HHS / United States
M01 RR000240 / RR / NCRR NIH HHS / United States
UL1 RR024134 / RR / NCRR NIH HHS / United States
M01 RR020359 / RR / NCRR NIH HHS / United States