Title | Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021. |
Publication Type | Publication |
Year of Publication | 2016 |
Authors | Ruan A, Tobin NH, Mulligan K, Rollie A, Li F, Sleasman J, Aldrovandi GM |
Journal | J Acquir Immune Defic Syndr |
Volume | 72 |
Issue | 4 |
Pagination | 372-5 |
Date Published | 2016 Aug 01 |
ISSN | 1944-7884 |
Keywords | Absorptiometry, Photon, Adolescent, Adult, Antiretroviral Therapy, Highly Active, Bone Density, Bone Diseases, Metabolic, Cross-Sectional Studies, Female, HIV Infections, Humans, Macrophage Activation, Male, Osteoporosis, Puerto Rico, Sex Factors, Spine, United States, Young Adult |
Abstract | <p>Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than females. Of 11 biomarkers assessed by sex and HIV-status, HIV-infected males had increased levels of soluble CD14 which inversely correlated with bone mineral content and bone mineral density measures, suggesting macrophage activation as a possible mechanism of differential bone loss.</p> |
DOI | 10.1097/QAI.0000000000000953 |
Alternate Journal | J Acquir Immune Defic Syndr |
PubMed ID | 26885808 |
PubMed Central ID | PMC4925249 |
Grant List | U01 HD040533 / HD / NICHD NIH HHS / United States U01 HD040474 / HD / NICHD NIH HHS / United States UL1 RR024131 / RR / NCRR NIH HHS / United States M01 RR000071 / RR / NCRR NIH HHS / United States M01 RR001271 / RR / NCRR NIH HHS / United States M01 RR000043 / RR / NCRR NIH HHS / United States M01 RR000240 / RR / NCRR NIH HHS / United States UL1 RR024134 / RR / NCRR NIH HHS / United States M01 RR020359 / RR / NCRR NIH HHS / United States |