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Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos.

TitleActigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2021
AuthorsAgudelo C, Tarraf W, Wu B, Wallace DM, Patel SR, Redline S, Kaur S, Daviglus M, Zee PC, Simonelli G, Mossavar-Rahmani Y, Sotres-Alvarez D, Zeng D, Gallo LC, González HM, Ramos AR
JournalAlzheimers Dement
Volume17
Issue6
Pagination959-968
Date Published2021 06
ISSN1552-5279
Abstract

INTRODUCTION: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults.METHODS: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates.RESULTS: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change.CONCLUSION: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.

DOI10.1002/alz.12250
Alternate JournalAlzheimers Dement
PubMed ID33350583
PubMed Central IDPMC8312581
Grant ListR01HL098297 / / National Heart Lung Blood Institute /
N01-HC65237 / / San Diego State University /
R21 HL140437 / HL / NHLBI NIH HHS / United States
R01AG048642 / AG / NIA NIH HHS / United States
RF1AG061022 / AG / NIA NIH HHS / United States
R21 AG056952 / AG / NIA NIH HHS / United States
N01-HC65233 / / University of North Carolina /
R01 HL098297 / HL / NHLBI NIH HHS / United States
R01 AG048642 / AG / NIA NIH HHS / United States
RF1 AG061022 / AG / NIA NIH HHS / United States
N01-HC65235 / / Albert Einstein College of Medicine /
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01-HC65236 / / Northwestern University /
N01-HC65234 / / University of Miami /
RF1 AG054548 / AG / NIA NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
R01 AG067568 / AG / NIA NIH HHS / United States
R21AG056952 / AG / NIA NIH HHS / United States
RF1AG054548 / AG / NIA NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
MS#: 
0859
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Miami (University of Miami)
ECI: 
Manuscript Affiliation: 
Field Center: Miami (University of Miami)
Manuscript Status: 
Published