|Title||APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).|
|Authors||Granot-Hershkovitz E, Tarraf W, Kurniansyah N, Daviglus M, Isasi CR, Kaplan R, Lamar M, Perreira KM, Wassertheil-Smoller S, Stickel A, Thyagarajan B, Zeng D, Fornage M, DeCarli CS, González HM, Sofer T|
|Date Published||2021 03|
|Keywords||Aged, aging, Alleles, Alzheimer Disease, Apolipoprotein E4, Caribbean Region, Cognition, Cognitive Dysfunction, Female, Genotype, Hispanic or Latino, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, South America, United States|
INTRODUCTION: Apolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry-specific genetic effects.METHODS: We investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, stratified by six Latino backgrounds, and explored whether the proportion of continental genetic ancestry (European, African, and Amerindian) modifies these associations.RESULTS: APOE ε4 was associated with an increased risk of significant cognitive decline (odds ratio [OR] = 1.15, P-value = 0.03), with the strongest association in Cubans (OR = 1.46, P-value = 0.007). APOE-ε2 was associated with decreased risk of MCI (OR = 0.37, P-value = 0.04) in Puerto Ricans. Amerindian genetic ancestry was found to protect from the risk conferred by APOE ε4 on significant cognitive decline.DISCUSSION: Results suggest that APOE alleles' effects on cognitive outcomes differ across six Latino backgrounds and are modified by continental genetic ancestry.
|Alternate Journal||Alzheimers Dement|
|PubMed Central ID||PMC8016734|
|Grant List||P30 AG062429 / AG / NIA NIH HHS / United States |
P30 AG010129 / AG / NIA NIH HHS / United States
R01 AG048642 / AG / NIA NIH HHS / United States
RF1 AG061022 / AG / NIA NIH HHS / United States
R56 AG048642 / AG / NIA NIH HHS / United States
RF1 AG054548 / AG / NIA NIH HHS / United States
APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).