Accessibility issues or difficulties with this website?
Call 919-962-2073 or email hchsadministration@unc.edu.

Latent profiles of global electrical heterogeneity: the Hispanic Community Health Study/Study of Latinos.

TitleLatent profiles of global electrical heterogeneity: the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2024
AuthorsTereshchenko LG, Haq KT, Howell SJ, Mitchell EC, Martínez J, Hyde J, Briceno G, Pena J, Pocius E, Khan A, Soliman EZ, Lima JAC, Kapadia SR, Misra-Hebert AD, Kattan MW, Kansal MM, Daviglus ML, Kaplan R
JournalEur Heart J Digit Health
Volume5
Issue5
Pagination611-621
Date Published2024 Sep
ISSN2634-3916
Abstract

AIMS: Despite the highest prevalence of stroke, obesity, and diabetes across races/ethnicities, paradoxically, Hispanic/Latino populations have the lowest prevalence of atrial fibrillation and major Minnesota code-defined ECG abnormalities. We aimed to use Latent Profile Analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population to obtain insight into epidemiological discrepancies.METHODS AND RESULTS: We conducted a cross-sectional analysis of baseline HCHS/SOL visit. Global electrical heterogeneity (GEH) was measured as spatial QRS-T angle (QRSTa), spatial ventricular gradient azimuth (SVGaz), elevation (SVGel), magnitude (SVGmag), and sum absolute QRST integral (SAIQRST). Statistical analysis accounted for the stratified two-stage area probability sample design. We fitted a multivariate latent profile generalized structural equation model adjusted for age, sex, ethnic background, education, hypertension, diabetes, smoking, dyslipidaemia, obesity, chronic kidney disease, physical activity, diet quality, average RR' interval, median beat type, and cardiovascular disease (CVD) to gain insight into the GEH profiles. Among 15 684 participants (age 41 years; 53% females; 6% known CVD), 17% had an increased probability of likely abnormal GEH profile (QRSTa 80 ± 27°, SVGaz -4 ± 21°, SVGel 72 ± 12°, SVGmag 45 ± 12 mVms, and SAIQRST 120 ± 23 mVms). There was a 23% probability for a participant of being in Class 1 with a narrow QRSTa (40.0 ± 10.2°) and large SVG (SVGmag 108.3 ± 22.6 mVms; SAIQRST 203.4 ± 39.1 mVms) and a 60% probability of being in intermediate Class 2.CONCLUSION: A substantial proportion (17%) in the Hispanic/Latino population had an increased probability of altered, likely abnormal GEH profile, whereas 83% of the population was resilient to harmful risk factors exposures.

DOI10.1093/ehjdh/ztae048
Alternate JournalEur Heart J Digit Health
PubMed ID39318685
PubMed Central IDPMC11417492
Grant ListR01 HL118277 / HL / NHLBI NIH HHS / United States
R56 HL118277 / HL / NHLBI NIH HHS / United States
MS#: 
0924
Manuscript Lead/Corresponding Author Affiliation: 
Ancillary Study Investigators - Not at HCHS/SOL site
ECI: 
Manuscript Affiliation: 
Coordinating Center - Collaborative Studies Coordinating Center - UNC at Chapel Hill
Manuscript Status: 
Published