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Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos.

TitleSleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2016
AuthorsRamos AR, Tarraf W, Daviglus M, Davis S, Gallo LC, Mossavar-Rahmani Y, Penedo FJ, Redline S, Rundek T, Sacco RL, Sotres-Alvarez D, Wright CB, Zee PC, González HM
JournalSleep
Volume39
Issue10
Pagination1843-1851
Date Published2016 Oct 01
ISSN1550-9109
KeywordsAged, Cognition, Cohort Studies, Community Health Services, Cross-Sectional Studies, Female, Hispanic Americans, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Residence Characteristics, Self Report, sleep, Time Factors, United States
Abstract

STUDY OBJECTIVES: To evaluate the association between sleep duration and neurocognitive function in a representative sample of middle-aged to older Hispanic/Latino adults in the US. We tested the hypothesis that sleep duration has a nonlinear, inverted U-shaped association with neurocognitive function.METHODS: We performed a cross-sectional analysis from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants ages 45-74 years (n = 8,676). HCHS/SOL is a community-based cohort from four US urban areas sampled using a probability design from 2008-2011. Self-reported sleep duration was calculated as a weighted average of the difference between habitual wake and bedtimes assessed by separate questions for weekdays and weekends. Neurocognitive function was measured with standardized scores for Word (Phonemic) Fluency (WF), Brief-Spanish English Verbal learning test (B-SEVLT), and Digit Symbol Substitution (DSS) tests.RESULTS: The mean age was 56.5 years; 55% were women; and 40.4% had less than high school education. Average sleep duration was 7.8 ± 1.7 hours. There was an inverted U-shaped association with sleep duration and WF, B-SEVLT sum, and the DSS, with no association with B-SEVLT delayed-recall. Participants with intermediate sleep duration had the best neurocognitive function, while long sleepers had worse neurocognitive function adjusting for demographic, behavioral, and medical factors, daytime sleepiness, and use of sleep medications.CONCLUSIONS: Sleep duration had curvilinear inverted U-shaped associations with neurocognitive function, with worse scores among participants with longer sleep duration. These findings may provide a framework to further examine sleep duration in the prevention and treatment of neurocognitive disorders.

DOI10.5665/sleep.6166
Alternate JournalSleep
PubMed ID27450689
PubMed Central IDPMC5020366
Grant ListR01 AG048642 / AG / NIA NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
KL2 TR000461 / TR / NCATS NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01 HC065237 / HC / WHI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
UL1 TR001073 / TR / NCATS NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
MS#: 
0243
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Miami (University of Miami)
ECI: 
Manuscript Status: 
Published