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Objectively Measured Physical Activity, Sedentary Behavior, and Genetic Predisposition to Obesity in U.S. Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

TitleObjectively Measured Physical Activity, Sedentary Behavior, and Genetic Predisposition to Obesity in U.S. Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Publication TypePublication
Year2017
AuthorsMoon J-Y, Wang T, Sofer T, North KE, Isasi CR, Cai J, Gellman MD, Moncrieft AE, Sotres-Alvarez D, Argos M, Kaplan RC, Qi Q
JournalDiabetes
Volume66
Issue12
Pagination3001-3012
Date Published2017 12
ISSN1939-327X
Keywordsadiposity, Adolescent, Adult, Aged, Body mass index, exercise, Female, Genetic Predisposition to Disease, Hispanic Americans, Humans, Male, Middle Aged, Obesity, Sedentary Behavior, Young Adult
Abstract

Studies using self-reported data suggest a gene-physical activity interaction on obesity, yet the influence of sedentary behavior, distinct from a lack of physical activity, on genetic associations with obesity remains unclear. We analyzed interactions of accelerometer-measured moderate to vigorous physical activity (MVPA) and time spent sedentary with genetic variants on obesity among 9,645 U.S. Hispanics/Latinos. An overall genetic risk score (GRS), a central nervous system (CNS)-related GRS, and a non-CNS-related GRS were calculated based on 97 BMI-associated single nucleotide polymorphisms (SNPs). Genetic association with BMI was stronger in individuals with lower MVPA (first tertile) versus higher MVPA (third tertile) (β = 0.78 kg/m [SE, 0.10 kg/m] vs. 0.39 kg/m [0.09 kg/m] per SD increment of GRS; = 0.005), and in those with more time spent sedentary (third tertile) versus less time spent sedentary (first tertile) (β = 0.73 kg/m [SE, 0.10 kg/m] vs. 0.44 kg/m [0.09 kg/m]; = 0.006). Similar significant interaction patterns were observed for obesity risk, body fat mass, fat percentage, fat mass index, and waist circumference, but not for fat-free mass. The CNS-related GRS, but not the non-CNS-related GRS, showed significant interactions with MVPA and sedentary behavior, with effects on BMI and other adiposity traits. Our data suggest that both increasing physical activity and reducing sedentary behavior may attenuate genetic associations with obesity, although the independence of these interaction effects needs to be investigated further.

DOI10.2337/db17-0573
Alternate JournalDiabetes
PubMed ID28986399
PubMed Central IDPMC5697950
Grant ListK01 HL129892 / HL / NHLBI NIH HHS / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
P30 DK111022 / DK / NIDDK NIH HHS / United States
T42 OH008672 / OH / NIOSH CDC HHS / United States
MS#: 
0498
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
ECI: 
Manuscript Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status: 
Published