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Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos.

TitleAssociation of occupational exposures with cardiovascular disease among US Hispanics/Latinos.
Publication TypePublication
Year2019
AuthorsBulka CM, Daviglus ML, Persky VW, Durazo-Arvizu RA, Lash JP, Elfassy T, Lee DJ, Ramos AR, Tarraf W, Argos M
JournalHeart
Volume105
Issue6
Pagination439-448
Date Published2019 03
ISSN1468-201X
KeywordsAcculturation, Adult, Aged, Cardiotoxins, Cardiovascular Diseases, Cross-Sectional Studies, Female, Hispanic Americans, Humans, Life Style, Male, Metals, Middle Aged, Occupational Exposure, Pesticides, Prevalence, Risk Factors, Socioeconomic Factors, United States
Abstract

OBJECTIVE: Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers.METHODS: Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed. Participants from four US cities provided questionnaire data and underwent clinical examinations, including ECGs. CVD was defined as the presence of at least one of the following: coronary heart disease, atrial fibrillation, heart failure or cerebrovascular disease. Prevalence ratios reflecting the relationship between each occupational exposure and CVD as well as CVD subtypes were calculated using Poisson regression models.RESULTS: Hispanic/Latino workers reported exposures to organic solvents (6.5%), metals (8.5%) and pesticides (4.7%) at their current jobs. Overall, 6.1% of participants had some form of CVD, with coronary heart disease as the most common (4.3%) followed by cerebrovascular disease (1.0%), heart failure (0.8%) and atrial fibrillation (0.7%). For individuals who reported working with pesticides, the prevalence ratios for any CVD were 2.18 (95% CI 1.34 to 3.55), coronary heart disease 2.20 (95% CI 1.31 to 3.71), cerebrovascular disease 1.38 (95% CI 0.62 3.03), heart failure 0.91 (95% CI 0.23 to 3.54) and atrial fibrillation 5.92 (95% CI 1.89 to 18.61) after adjustment for sociodemographic, acculturation, lifestyle and occupational characteristics. Metal exposures were associated with an almost fourfold (3.78, 95% CI 1.24 to 11.46) greater prevalence of atrial fibrillation. Null associations were observed for organic solvent exposures.CONCLUSIONS: Our results suggest that working with metals and pesticides could be risk factors for CVD among Hispanic/Latino workers. Further work is needed to evaluate these relationships prospectively.

DOI10.1136/heartjnl-2018-313463
Alternate JournalHeart
PubMed ID30538094
PubMed Central IDPMC6580877
Grant ListKL2 TR002737 / TR / NCATS NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
R21 HL140437 / HL / NHLBI NIH HHS / United States
T32 HL125294 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
HHSN268201300003C / HG / NHGRI NIH HHS / United States
R21 AG056952 / AG / NIA NIH HHS / United States
MS#: 
0509
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Chicago (University of Illinois at Chicago)
ECI: 
Manuscript Affiliation: 
Field Center: Chicago (University of Illinois at Chicago)
Manuscript Status: 
Published