Title | Metabolic Syndrome in Hispanic Youth: Results from the Hispanic Community Children's Health Study/Study of Latino Youth. |
Publication Type | Publication |
Year | 2017 |
Authors | Reina SA, Llabre MM, Vidot DC, Isasi CR, Perreira K, Carnethon M, Parrinello CM, Gallo LC, Ayala GX, Delamater A |
Journal | Metab Syndr Relat Disord |
Volume | 15 |
Issue | 8 |
Pagination | 400-406 |
Date Published | 2017 Oct |
ISSN | 1557-8518 |
Keywords | Adolescent, Cardiovascular Diseases, Child, Child Health, Female, Hispanic or Latino, Humans, Male, Metabolic syndrome, Nutrition Surveys, Residence Characteristics, Risk Factors |
Abstract | BACKGROUND: Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, is being diagnosed in youth. Specific diagnostic criteria used to define MetS influence prevalence estimates and populations considered at risk for cardiovascular disease. The National Cholesterol Education Program's Adult Treatment Panel III (ATP), the World Health Organization (WHO), and the International Diabetes Federation (IDF) provide three MetS definitions used in medical research. This study examined concordance among these definitions in 1137 children 10-16 years of age, who participated in the Hispanic Community Children's Health Study/Study of Latino Youth.METHODS: Prevalence of MetS and of individual components was estimated using SAS. Mplus was used to test a single-factor model of MetS components (triglycerides, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, waist circumference, and fasting glucose).RESULTS: The ATP definition identified most MetS cases in 10-15 (N = 19, 4.7%) and 16-year-old girls (N = 3, 7.3%). The IDF definition identified most cases of MetS in 10-15 (N = 16, 3.1%) and 16-year-old boys (N = 2, 2.8%). Fewest cases of MetS were identified with the WHO definition across age and sex groups.CONCLUSION: Only one participant was classified as having MetS across all three definitions. Confirmatory factor analysis indicated fasting glucose and systolic blood pressure did not reliably cluster with other risk factors that define MetS in Hispanic/Latino adolescents. We conclude that prevalence estimates of MetS in youth are unstable across current criteria, calling into question the accuracy of defining and diagnosing MetS in youth. |
DOI | 10.1089/met.2017.0054 |
Alternate Journal | Metab Syndr Relat Disord |
PubMed ID | 28829223 |
PubMed Central ID | PMC5649400 |
Grant List | N01HC65236 / HL / NHLBI NIH HHS / United States T32 HL007426 / HL / NHLBI NIH HHS / United States N01HC65237 / HL / NHLBI NIH HHS / United States N01HC65234 / HL / NHLBI NIH HHS / United States N01HC65235 / HL / NHLBI NIH HHS / United States N01HC65233 / HL / NHLBI NIH HHS / United States P30 DK111022 / DK / NIDDK NIH HHS / United States P2C HD050924 / HD / NICHD NIH HHS / United States R01 HL102130 / HL / NHLBI NIH HHS / United States |
Metabolic Syndrome in Hispanic Youth: Results from the Hispanic Community Children's Health Study/Study of Latino Youth.
MS#:
0317
ECI:
Yes
Manuscript Status:
Published