Title | Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL). |
Publication Type | Publication |
Year | 2020 |
Authors | González HM, Tarraf W, González KA, Fornage M, Zeng D, Gallo LC, Talavera GA, Daviglus ML, Lipton RB, Kaplan R, Ramos AR, Lamar M, Cai J, DeCarli C, Schneiderman N |
Journal | Diabetes Care |
Volume | 43 |
Issue | 5 |
Pagination | 1111-1117 |
Date Published | 2020 May |
ISSN | 1935-5548 |
Keywords | Aged, Aged, 80 and over, aging, California, Chicago, Cognitive Aging, Cognitive Dysfunction, Diabetes Complications, Diabetes Mellitus, Female, Florida, Hispanic or Latino, Humans, Male, Middle Aged, New York, Prevalence, Prospective Studies, Risk Factors, United States |
Abstract | OBJECTIVE: Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos.RESEARCH DESIGN AND METHODS: The Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) is an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability-sampled (i.e., representative of targeted populations), and prospective cohort study. Between 2016 and 2018, SOL-INCA enrolled diverse Hispanics/Latinos aged ≥50 years ( = 6,377). Global cognitive decline and mild cognitive impairment (MCI) were the primary outcomes.RESULTS: Prevalent diabetes at visit 1, but not incident diabetes at visit 2, was associated with significantly steeper global cognitive decline (β = -0.16 [95% CI -0.25; -0.07]; < 0.001), domain-specific cognitive decline, and higher odds of MCI (odds ratio 1.74 [95% CI 1.34; 2.26]; < 0.001) compared with no diabetes in age- and sex-adjusted models.CONCLUSIONS: Diabetes was associated with cognitive decline and increased MCI prevalence among diverse Hispanics/Latinos, primarily among those with prevalent diabetes at visit 1. Our findings suggest that significant cognitive decline and MCI may be considered additional disease complications of diabetes among diverse middle-aged and older Hispanics/Latinos. |
DOI | 10.2337/dc19-1676 |
Alternate Journal | Diabetes Care |
PubMed ID | 32139382 |
PubMed Central ID | PMC7171942 |
Grant List | P30 AG059299 / AG / NIA NIH HHS / United States N01HC65236 / HL / NHLBI NIH HHS / United States N01HC65237 / HL / NHLBI NIH HHS / United States P30 DK020541 / DK / NIDDK NIH HHS / United States UL1 TR002550 / TR / NCATS NIH HHS / United States P60 DK020541 / DK / NIDDK NIH HHS / United States R21 AG056952 / AG / NIA NIH HHS / United States R01 AG048642 / AG / NIA NIH HHS / United States RF1 AG061022 / AG / NIA NIH HHS / United States N01HC65235 / HL / NHLBI NIH HHS / United States P30 AG062429 / AG / NIA NIH HHS / United States RF1 AG054548 / AG / NIA NIH HHS / United States N01HC65234 / HL / NHLBI NIH HHS / United States P30 DK111022 / DK / NIDDK NIH HHS / United States N01HC65233 / HL / NHLBI NIH HHS / United States |
Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL).
MS#:
0596
ECI:
Manuscript Affiliation:
HCHS/SOL Baseline Visit - Neurocognitive Reading Center
Manuscript Status:
Published