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Association Between Sleep Disordered Breathing and Left Ventricular Function: A Cross-Sectional Analysis of the ECHO-SOL Ancillary Study.

TitleAssociation Between Sleep Disordered Breathing and Left Ventricular Function: A Cross-Sectional Analysis of the ECHO-SOL Ancillary Study.
Publication TypePublication
Year2020
AuthorsOgilvie RP, Genuardi MV, Magnani JW, Redline S, Daviglus ML, Shah N, Kansal M, Cai J, Ramos AR, Hurwitz BE, Ponce S, Patel SR, Rodriguez CJ
JournalCirc Cardiovasc Imaging
Volume13
Issue5
Paginatione009074
Date Published2020 05
ISSN1942-0080
KeywordsAdolescent, Adult, Aged, Cross-Sectional Studies, Diastole, Echocardiography, Female, Heart Failure, Hispanic Americans, Humans, Hypertrophy, Left Ventricular, Lung, Male, Middle Aged, Prevalence, Prognosis, Prospective Studies, Race Factors, Respiration, Risk Assessment, Risk Factors, Severity of Illness Index, sleep, Sleep Apnea Syndromes, United States, Ventricular Dysfunction, Left, Ventricular Function, Left, Ventricular Remodeling, Young Adult
Abstract

BACKGROUND: Prior studies have found that sleep-disordered breathing (SDB) is common among those with left ventricular (LV) dysfunction and heart failure. Few epidemiological studies have examined this association, especially in US Hispanic/Latinos, who may be at elevated risk of SDB and heart failure.METHODS: We examined associations between SDB and LV diastolic and systolic function using data from 1506 adults aged 18 to 64 years in the Hispanic Community Health Study/Study of Latinos ECHO-SOL Ancillary Study (2011-2014). Home sleep testing was used to measure the apnea-hypopnea index, a measure of SDB severity. Echocardiography was performed a median of 2.1 years later to quantify LV diastolic function, systolic function, and structure. Multivariable linear regression was used to model the association between apnea-hypopnea index and echocardiographic measures while accounting for the complex survey design, demographics, body mass, and time between sleep and echocardiographic measurements.RESULTS: Each 10-unit increase in apnea-hypopnea index was associated with 0.2 (95% CI, 0.1-0.3) lower E', 0.3 (0.1-0.5) greater E/E' ratio, and 1.07-fold (1.03-1.11) higher prevalence of diastolic dysfunction as well as 1.3 (0.3-2.4) g/m greater LV mass index. These associations persisted after adjustment for hypertension and diabetes mellitus. In contrast, no association was identified between SDB severity and subclinical markers of LV systolic function.CONCLUSIONS: Greater SDB severity was associated with LV hypertrophy and subclinical markers of LV diastolic dysfunction. These findings suggest SDB in Hispanic/Latino men and women may contribute to the burden of heart failure in this population.

DOI10.1161/CIRCIMAGING.119.009074
Alternate JournalCirc Cardiovasc Imaging
PubMed ID32408831
PubMed Central IDPMC8117672
Grant ListK24 HL127307 / HL / NHLBI NIH HHS / United States
R01 HL104199 / HL / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
R21 HL140437 / HL / NHLBI NIH HHS / United States
T32 HL082610 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
R01 HL143221 / HL / NHLBI NIH HHS / United States
R21 AG056952 / AG / NIA NIH HHS / United States
T32 HL083825 / HL / NHLBI NIH HHS / United States
MS#: 
0694
Manuscript Lead/Corresponding Author Affiliation: 
Affiliated Investigator - Not at HCHS/SOL site
ECI: 
Yes
Manuscript Status: 
Published