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Phenotypes of Obstructive Sleep Apnea in the Hispanic Community Health Study/Study of Latinos

TitlePhenotypes of Obstructive Sleep Apnea in the Hispanic Community Health Study/Study of Latinos
Publication TypePublication
AuthorsGonzález KA, Tarraf W, Wallace DM, Stickel AM, Schneiderman N, Redline S, Patel SR, Gallo LC, Mossavar-Rahmani Y, Daviglus ML, Zee PC, Talavera GA, Sotres-Alvarez D, González HM, Ramos A
Date Published2021 Jul 17

STUDY OBJECTIVES: Recent work on US Whites from clinical samples used obstructive sleep apnea (OSA) symptoms to generate phenotypes for individuals with moderate-severe OSA which suggested 3 to 5 symptom classes. However, it is unknown whether similar classes generalize to diverse Hispanics/Latino adults. Therefore, we sought to fill this gap by empirically deriving sleep phenotypes among a large sample of diverse Hispanics/Latinos.

METHODS: We used data from The Hispanic Community Health Study/Study of Latinos (HCHS/SOL; 2008-2011), a prospective cohort study designed using a multisite multistage probability sample of adults 18-74 years old. The subpopulation of interest included participants with moderate-severe OSA symptoms (≥15 respiratory event index (REI) events per hour; n=1,605). We performed latent class analysis for complex survey data using 15 common OSA symptoms (e.g. Epworth Sleepiness Scale) and four comorbidities to identify phenotype classes.

RESULTS: Average age was 52.4 ± 13.9 years and 34.0% were female. Mean respiratory event index was 33.8 ± 22.5 events per hour. Fit statistics and clinical significance suggested that a three-class solution provided best fit to the data. The three phenotypes were: 1) Minimally Symptomatic (47.7%), 2) Excessive sleepiness (37.1%), and (3) Disturbed Sleep (15.2%). Sensitivity models were consistent with main proposed solution.

CONCLUSIONS: Derived sleep phenotypes among diverse Hispanic/Latinos were consistent with recent findings from the Sleep Apnea Global Interdisciplinary Consortium, but we found notable differences in class prevalence relative to Whites. Further research is needed to link derived sleep phenotypes to health comorbidities in diverse populations.

Alternate JournalSleep
PubMed ID34272952
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Miami (University of Miami)
Manuscript Affiliation: 
Field Center: Miami (University of Miami)
Manuscript Status: