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Phenotypes of obstructive sleep apnea in the Hispanic Community Health Study/Study of Latinos.

TitlePhenotypes of obstructive sleep apnea in the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2021
AuthorsGonzález KA, Tarraf W, Wallace DM, Stickel AM, Schneiderman N, Redline S, Patel SR, Gallo LC, Mossavar-Rahmani Y, Daviglus ML, Zee PC, Talavera GA, Sotres-Alvarez D, González HM, Ramos A
JournalSleep
Volume44
Issue12
Date Published2021 12 10
ISSN1550-9109
KeywordsFemale, Hispanic or Latino, Humans, Phenotype, Prospective Studies, Public Health, Sleep Apnea, Obstructive
Abstract

STUDY OBJECTIVES: Recent work on US Whites from clinical samples used obstructive sleep apnea (OSA) symptoms to generate phenotypes for individuals with moderate-severe OSA which suggested 3 to 5 symptom classes. However, it is unknown whether similar classes generalize to diverse Hispanics/Latino adults. Therefore, we sought to fill this gap by empirically deriving sleep phenotypes among a large sample of diverse Hispanics/Latinos.METHODS: We used data from The Hispanic Community Health Study/Study of Latinos (HCHS/SOL; 2008-2011), a prospective cohort study designed using a multisite multistage probability sample of adults 18-74 years old. The subpopulation of interest included participants with moderate-severe OSA symptoms (≥15 respiratory event index (REI) events per hour; n = 1,605). We performed latent class analysis for complex survey data using 15 common OSA symptoms (e.g. Epworth Sleepiness Scale) and 4 comorbidities to identify phenotype classes.RESULTS: Average age was 52.4 ± 13.9 years and 34.0% were female. Mean REI was 33.8 ± 22.5 events per hour. Fit statistics and clinical significance suggested that a three-class solution provided the best fit to the data. The three phenotypes were: (1) Minimally Symptomatic (47.7%), (2) Excessive sleepiness (37.1%), and (3) Disturbed Sleep (15.2%). Sensitivity models were consistent with the main proposed solution.CONCLUSIONS: Derived sleep phenotypes among diverse Hispanic/Latinos were consistent with recent findings from the Sleep Apnea Global Interdisciplinary Consortium, but we found notable differences in class prevalence relative to Whites. Further research is needed to link derived sleep phenotypes to health comorbidities in diverse populations.

DOI10.1093/sleep/zsab181
Alternate JournalSleep
PubMed ID34272952
PubMed Central IDPMC8664595
Grant ListL30 AG074401 / AG / NIA NIH HHS / United States
P30 AG059299 / AG / NIA NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
R21 HL140437 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
R56 AG048642 / AG / NIA NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
MS#: 
0930
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Miami (University of Miami)
ECI: 
Yes
Manuscript Affiliation: 
Field Center: Miami (University of Miami)
Manuscript Status: 
Published