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The Association of Stress, Metabolic Syndrome and Systemic Inflammation with Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos and its Sociocultural Ancillary Study

TitleThe Association of Stress, Metabolic Syndrome and Systemic Inflammation with Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos and its Sociocultural Ancillary Study
Publication TypePublication
Year2021
AuthorsMarquine MJ, Gallo LC, Tarraf W, Wu B, Moore AA, Vásquez PM, Talavera G, Allison M, Muñoz E, Isasi CR, Perreira KM, Bigornia SJ, Daviglus M, Estrella ML, Zeng D, González HM
JournalJ Gerontol B Psychol Sci Soc Sci
Date Published2021 Aug 11
ISSN1758-5368
Abstract

OBJECTIVES: Identifying sociocultural correlates of neurocognitive dysfunction among Hispanics/Latinos, and their underlying biological pathways, is crucial for understanding disparities in Alzheimer's disease and related dementias. We examined cross-sectional associations between stress and neurocognition, and the role that metabolic syndrome (MetS) and systemic inflammation might play in these associations.

METHOD: Participants included 3,045 adults aged 45-75 (56% female, education 0-20+ years, 86% Spanish-speaking, 23% US born), enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and its Sociocultural Ancillary Study. Global neurocognition was the primary outcome and operationalized as the average of the z-scores of measures of learning and memory, word fluency, and processing speed. Stress measures included self-report assessments of stress appraisal (perceived and acculturative stress) and exposure to chronic and traumatic stressors. MetS was defined via established criteria including waist circumference, high blood pressure, elevated triglycerides, fasting plasma glucose, and high HDL-cholesterol. Systemic inflammation was represented by high sensitivity C-reactive protein (hs-CRP).

RESULTS: Separate survey multivariable linear regression models adjusting for covariates, showed that higher perceived (b=-0.004, SE=0.002, p

DISCUSSION: These cross-sectional analyses suggest that stress appraisal, MetS and systemic inflammation may be targets to reduce neurocognitive dysfunction among Hispanics/Latinos.

DOI10.1093/geronb/gbab150
Alternate JournalJ Gerontol B Psychol Sci Soc Sci
PubMed ID34378777
MS#: 
0832
Manuscript Lead/Corresponding Author Affiliation: 
Affiliated Investigator - Not at HCHS/SOL site
ECI: 
Yes
Manuscript Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status: 
Published