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The Association of Stress, Metabolic Syndrome, and Systemic Inflammation With Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos and Its Sociocultural Ancillary Study.

TitleThe Association of Stress, Metabolic Syndrome, and Systemic Inflammation With Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos and Its Sociocultural Ancillary Study.
Publication TypePublication
Year2022
AuthorsMarquine MJ, Gallo LC, Tarraf W, Wu B, Moore AA, Vásquez PM, Talavera G, Allison M, Muñoz E, Isasi CR, Perreira KM, Bigornia SJ, Daviglus M, Estrella ML, Zeng D, González HM
JournalJ Gerontol B Psychol Sci Soc Sci
Volume77
Issue5
Pagination860-871
Date Published2022 05 05
ISSN1758-5368
KeywordsC-Reactive Protein, Cross-Sectional Studies, Female, Hispanic or Latino, Humans, Inflammation, Male, Metabolic syndrome, Risk Factors, Self Report
Abstract

OBJECTIVES: Identifying sociocultural correlates of neurocognitive dysfunction among Hispanics/Latinos, and their underlying biological pathways, is crucial for understanding disparities in Alzheimer's disease and related dementias. We examined cross-sectional associations between stress and neurocognition, and the role that metabolic syndrome (MetS) and systemic inflammation might play in these associations.METHOD: Participants included 3,045 adults aged 45-75 (56% female, education 0-20+ years, 86% Spanish-speaking, 23% U.S.-born), enrolled in the Hispanic Community Health Study/Study of Latinos and its Sociocultural Ancillary Study. Global neurocognition was the primary outcome and operationalized as the average of the z scores of measures of learning and memory, word fluency, and processing speed. Stress measures included self-report assessments of stress appraisal (perceived and acculturative stress) and exposure to chronic and traumatic stressors. MetS was defined via established criteria including waist circumference, high blood pressure, elevated triglycerides, fasting plasma glucose, and high levels of high-density lipoprotein cholesterol. Systemic inflammation was represented by high-sensitivity C-reactive protein (hs-CRP).RESULTS: Separate survey multivariable linear regression models adjusting for covariates showed that higher perceived (b = -0.004, SE = 0.002, p < .05) and acculturative stress (b = -0.004, SE = 0.001, p < .0001) were significantly associated with worse global neurocognition, while lifetime exposure to traumatic stressors was associated with better global neurocognition (b = 0.034, SE = 0.009, p < .001). Neither MetS nor hs-CRP were notable pathways in the association between stress and neurocognition; rather, they were both independently associated with worse neurocognition in models including stress measures (ps < .05).DISCUSSION: These cross-sectional analyses suggest that stress appraisal, MetS, and systemic inflammation may be targets to reduce neurocognitive dysfunction among Hispanics/Latinos.

DOI10.1093/geronb/gbab150
Alternate JournalJ Gerontol B Psychol Sci Soc Sci
PubMed ID34378777
PubMed Central IDPMC9071500
Grant ListHHSN268201300003I / / University of Illinois at Chicago /
P30 AG059299 / AG / NIA NIH HHS / United States
HHSN268201300001C / HL / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
HHSN268201300004I / / University of Miami /
RC2 HL101649 / HL / NHLBI NIH HHS / United States
HHSN268201300005I / / San Diego State University /
P2C HD050924 / HD / NICHD NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
P30 AG062429 / AG / NIA NIH HHS / United States
RF1 AG054548 / AG / NIA NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
P30 DK111022 / DK / NIDDK NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
HHSN268201300001I/ N01-HC-65233 / HL / NHLBI NIH HHS / United States
HHSN268201300002I / / Albert Einstein College of Medicine /
L60 MD015551 / MD / NIMHD NIH HHS / United States
MS#: 
0832
Manuscript Lead/Corresponding Author Affiliation: 
Affiliated Investigator - Not at HCHS/SOL site
ECI: 
Yes
Manuscript Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status: 
Published