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Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos.

TitleMetabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
AuthorsLee Y, Chen H, Chen W, Qi Q, Afshar M, Cai J, Daviglus ML, Thyagarajan B, North KE, London SJ, Boerwinkle E, Celedón JC, Kaplan RC, Yu B
Date Published2022 Apr 16

Asthma disproportionally affects Hispanic and/or Latino backgrounds; however, the relation between circulating metabolites and asthma remains unclear. We conducted a cross-sectional study associating 640 individual serum metabolites, as well as twelve metabolite modules, with asthma in 3347 Hispanic/Latino background participants (514 asthmatics, 15.36%) from the Hispanic/Latino Community Health Study/Study of Latinos. Using survey logistic regression, per standard deviation (SD) increase in 1-arachidonoyl-GPA (20:4) was significantly associated with 32% high odds of asthma after accounting for clinical risk factors (p = 6.27 × 10−5), and per SD of the green module, constructed using weighted gene co-expression network, was suggestively associated with 25% high odds of asthma (p = 0.006). In the stratified analyses by sex and Hispanic and/or Latino backgrounds, the effect of 1-arachidonoyl-GPA (20:4) and the green module was predominantly observed in women (OR = 1.24 and 1.37, p < 0.001) and people of Cuban and Puerto-Rican backgrounds (OR = 1.25 and 1.27, p < 0.01). Mutations in Fatty Acid Desaturase 2 (FADS2) affected the levels of 1-arachidonoyl-GPA (20:4), and Mendelian Randomization analyses revealed that high genetically regulated 1-arachidonoyl-GPA (20:4) levels were associated with increased odds of asthma (p < 0.001). The findings reinforce a molecular basis for asthma etiology, and the potential causal effect of 1-arachidonoyl-GPA (20:4) on asthma provides an opportunity for future intervention.

Alternate JournalMetabolites
PubMed ID35448546
PubMed Central IDPMC9028429
Grant ListP30 ES010126 / ES / NIEHS NIH HHS / United States
P30 ES030285 / ES / NIEHS NIH HHS / United States
Manuscript Lead/Corresponding Author Affiliation: 
Ancillary Study Investigators - Not at HCHS/SOL site
Manuscript Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status: