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Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.

TitlePlasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.
Publication TypePublication
Year2022
AuthorsGranot-Hershkovitz E, He S, Bressler J, Yu B, Tarraf W, Rebholz CM, Cai J, Chan Q, Garcia TP, Mosley T, Kristal BS, DeCarli C, Fornage M, Chen G-C, Qi Q, Kaplan R, González HM, Sofer T
JournalAlzheimers Dement
Date Published2022 Sep 16
ISSN1552-5279
Abstract

INTRODUCTION: We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations.METHODS: We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n = 1365) and African (n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function.RESULTS: Six metabolites were consistently associated with lower global cognitive function across all studies. Of these, four were sugar-related (e.g., ribitol). MR analyses provided weak evidence for a potential causal effect of ribitol on cognitive function and bi-directional effects of cognitive performance on diet.DISCUSSION: Several diet-related metabolites were associated with global cognitive function across studies with different race/ethnicities.HIGHLIGHTS: Metabolites associated with cognitive function in Puerto Rican adults were recently identified. We demonstrate the generalizability of these associations across diverse race/ethnicities. Most identified metabolites are related to sugars. Mendelian Randomization (MR) provides weak evidence for a causal effect of ribitol on cognitive function. Beta-cryptoxanthin and other metabolites highlight the importance of a healthy diet.

DOI10.1002/alz.12786
Alternate JournalAlzheimers Dement
PubMed ID36111689
Grant ListR21 AG070644 / AG / NIA NIH HHS / United States
RF1 AG054548 / AG / NIA NIH HHS / United States
RF1 AG061022 / AG / NIA NIH HHS / United States
MS#: 
1147
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Genetic Analysis Center - University of Washington, Seattle
ECI: 
Yes
Manuscript Status: 
Published