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Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.

TitlePlasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition.
Publication TypePublication
Year2023
AuthorsGranot-Hershkovitz E, He S, Bressler J, Yu B, Tarraf W, Rebholz CM, Cai J, Chan Q, Garcia TP, Mosley T, Kristal BS, DeCarli C, Fornage M, Chen G-C, Qi Q, Kaplan R, González HM, Sofer T
JournalAlzheimers Dement
Volume19
Issue4
Pagination1331-1342
Date Published2023 Apr
ISSN1552-5279
KeywordsBlack or African American, Cognition, Diet, Healthy, Diet, Mediterranean, Hispanic or Latino, Humans, Ribitol, United States, White
Abstract

INTRODUCTION: We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations.METHODS: We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n = 1365) and African (n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function.RESULTS: Six metabolites were consistently associated with lower global cognitive function across all studies. Of these, four were sugar-related (e.g., ribitol). MR analyses provided weak evidence for a potential causal effect of ribitol on cognitive function and bi-directional effects of cognitive performance on diet.DISCUSSION: Several diet-related metabolites were associated with global cognitive function across studies with different race/ethnicities.HIGHLIGHTS: Metabolites associated with cognitive function in Puerto Rican adults were recently identified. We demonstrate the generalizability of these associations across diverse race/ethnicities. Most identified metabolites are related to sugars. Mendelian Randomization (MR) provides weak evidence for a causal effect of ribitol on cognitive function. Beta-cryptoxanthin and other metabolites highlight the importance of a healthy diet.

DOI10.1002/alz.12786
Alternate JournalAlzheimers Dement
PubMed ID36111689
PubMed Central IDPMC10017373
Grant ListHHSN268201300005C / HL / NHLBI NIH HHS / United States
HHSN268201300004C / HL / NHLBI NIH HHS / United States
P30 AG059299 / AG / NIA NIH HHS / United States
RF1 AG059421 / AG / NIA NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201000001I / HL / NHLBI NIH HHS / United States
R01 AG048642 / AG / NIA NIH HHS / United States
RF1 AG061022 / AG / NIA NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
P30 AG062429 / AG / NIA NIH HHS / United States
RF1 AG054548 / AG / NIA NIH HHS / United States
HHSN261201300004I / CA / NCI NIH HHS / United States
HHSN268201300001C / HB / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
HHSN268201700002C / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
R21 AG070644 / AG / NIA NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201300003C / HG / NHGRI NIH HHS / United States
P30 AG066546 / AG / NIA NIH HHS / United States
U01 AG052409 / AG / NIA NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
P01 GM059299 / GM / NIGMS NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
R21 AG056952 / AG / NIA NIH HHS / United States
HHSN261201300005I / CA / NCI NIH HHS / United States
MS#: 
1147
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Genetic Analysis Center - University of Washington, Seattle
ECI: 
Yes
Manuscript Status: 
Published