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Association between gestational diabetes and 6-year incident diabetes: results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

TitleAssociation between gestational diabetes and 6-year incident diabetes: results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Publication TypePublication
Year2022
AuthorsCasagrande SS, M Avilés-Santa L, Sotres-Alvarez D, Gallo L, Simon M, Kominiarek M, Talavera G, Stuebe AM, Potter JN, Perera MJudith, Isasi C, Gonzalez JS, Rust K, Cowie C
JournalBMJ Open Diabetes Res Care
Volume10
Issue6
Date Published2022 Nov
ISSN2052-4897
KeywordsDiabetes Mellitus, Type 2, Diabetes, Gestational, Female, Hispanic or Latino, Humans, Male, Pregnancy, Public Health, Risk Factors
Abstract

OBJECTIVE: Type 2 diabetes and gestational diabetes (GDM) disproportionately affect those of Hispanic/Latino heritage. This study examined the association between GDM and prevalent and incident diabetes in a community-based study of Hispanic/Latina women living in the USA.METHODS: Participants were women aged 18-74 years in the Hispanic Community Health Study/Study of Latinos who had at least one pregnancy and had information on self-reported history of GDM at baseline (n=6389). Logistic regression was used to determine the association between GDM and prevalent (2008-2011) and incident (2014-2017) diabetes and interactions between GDM and risk factors for incident diabetes.RESULTS: At baseline, 8.7% of participants reported a history of GDM and 18.6% had prevalent diabetes. Women with Mexican heritage had the highest prevalence of GDM history (11.3%) vs women of Cuban (5.0%), Central American (4.9%), and South American (3.8%) heritage (p<0.001 for each comparison to Mexican heritage). Women with self-reported GDM were four times more likely to have prevalent diabetes compared with women without GDM, after adjusting for sociodemographic characteristics and cardiometabolic risk factors (adjusted OR (aOR)=3.94, 95% CI 2.75 to 5.64). Overall incidence of diabetes was 14.3/100 women. Women with GDM at baseline increased their odds of incident diabetes by threefold compared with women without GDM (aOR=3.25, 95% CI 2.09 to 5.05). Women with Cuban or Puerto Rican heritage and GDM had significantly higher odds of incident diabetes compared with women with Mexican heritage (aOR=2.15, 95% CI 1.17 to 3.95; aOR=1.95, 95% CI 1.07 to 3.55, respectively).CONCLUSION: Self-reported GDM was significantly associated with a threefold higher risk of incident diabetes among Hispanic/Latino women in the USA even after adjusting for several significant predictors of diabetes.

DOI10.1136/bmjdrc-2022-002980
Alternate JournalBMJ Open Diabetes Res Care
PubMed ID36375861
PubMed Central IDPMC9664292
Grant ListP30 DK020541 / DK / NIDDK NIH HHS / United States
P30 DK111022 / DK / NIDDK NIH HHS / United States
GS1-0F-00381L / DK / NIDDK NIH HHS / United States
MS#: 
0569
Manuscript Lead/Corresponding Author Affiliation: 
Affiliated Investigator - Not at HCHS/SOL site
ECI: 
Manuscript Affiliation: 
NIH Institution - NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
Manuscript Status: 
Published