Accessibility issues or difficulties with this website?
Call 919-962-2073 or email

Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos.

TitleGenetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
AuthorsZhang Y, Elgart M, Granot-Hershkovitz E, Wang H, Tarraf W, Ramos AR, Stickel AM, Zeng D, Garcia TP, Testai FD, Wassertheil-Smoller S, Isasi CR, Daviglus ML, Kaplan R, Fornage M, DeCarli C, Redline S, González HM, Sofer T
Date Published2023 Jan
Keywordsaging, Cognition, Cognitive Dysfunction, Disorders of Excessive Somnolence, genome-wide association study, Hispanic or Latino, Humans, Self Report, sleep, Sleep Initiation and Maintenance Disorders

BACKGROUND: Sleep phenotypes have been reported to be associated with cognitive ageing outcomes. However, there is limited research using genetic variants as proxies for sleep traits to study their associations. We estimated associations between Polygenic Risk Scores (PRSs) for sleep duration, insomnia, daytime sleepiness, and obstructive sleep apnoea (OSA) and measures of cogntive ageing in Hispanic/Latino adults.METHODS: We used summary statistics from published genome-wide association studies to construct PRSs representing the genetic basis of each sleep trait, then we studied the association of the PRSs of the sleep phenotypes with cognitive outcomes in the Hispanic Community Healthy Study/Study of Latinos. The primary model adjusted for age, sex, study centre, and measures of genetic ancestry. Associations are highlighted if their p-value <0.05.FINDINGS: Higher PRS for insomnia was associated with lower global cognitive function and higher risk of mild cognitive impairment (MCI) (OR = 1.20, 95% CI [1.06, 1.36]). Higher PRS for daytime sleepiness was also associated with increased MCI risk (OR = 1.14, 95% CI [1.02, 1.28]). Sleep duration PRS was associated with reduced MCI risk among short and normal sleepers, while among long sleepers it was associated with reduced global cognitive function and with increased MCI risk (OR = 1.40, 95% CI [1.10, 1.78]). Furthermore, adjustment of analyses for the measured sleep phenotypes and APOE-ε4 allele had minor effects on the PRS associations with the cognitive outcomes.INTERPRETATION: Genetic measures underlying insomnia, daytime sleepiness, and sleep duration are associated with MCI risk. Genetic and self-reported sleep duration interact in their effect on MCI.FUNDING: Described in Acknowledgments.

Alternate JournalEBioMedicine
PubMed ID36493726
PubMed Central IDPMC9732133
Grant ListR01 AG067568 / AG / NIA NIH HHS / United States
R01 HL161012 / HL / NHLBI NIH HHS / United States
R21 AG070644 / AG / NIA NIH HHS / United States
R25 NS117367 / NS / NINDS NIH HHS / United States
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Baseline Visit - Sleep Center - Harvard Medical School/The Brigham & Women's Hospital
Manuscript Status: