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Polygenic risk scores and kidney traits in the Hispanic/Latino population: The Hispanic Community Health Study/Study of Latinos

Title Polygenic risk scores and kidney traits in the Hispanic/Latino population: The Hispanic Community Health Study/Study of Latinos
Publication TypePublication
Year2023
AuthorsZhou LY, Sofer T, Horimoto ARVR, Talavera GA, Lash JP, Cai J, Franceschini N
JournalHGG Adv
Volume4
Issue2
Pagination100177
Date Published2023 Apr 13
ISSN2666-2477
Keywordsgenome-wide association study, Hispanic or Latino, Humans, Kidney, Public Health, Renal Insufficiency, Chronic, Risk Factors
Abstract

Estimated glomerular filtration rate (eGFR) is used to evaluate kidney function and determine the presence of chronic kidney disease (CKD), a highly prevalent disease in the US that varies among subgroups of Hispanic/Latino individuals. The polygenic risk score (PRS) is a popular method that uses large genome-wide association studies (GWASs) to provide a strong estimate of disease risk. However, due to the limited availability of summary statistics from GWAS meta-analyses based on Hispanic/Latino populations, PRSs can only be computed using different ancestry GWASs. The performance of eGFR PRSs derived from other GWAS reference populations for Hispanic/Latino population has not been examined. We compared PRS constructions for eGFR prediction in Hispanic/Latino individuals using GWAS-significant variants, clumping and thresholding (C&T), and PRS-CS, as well as a combination of PRSs calculated with different reference GWAS meta-analyses from European and multi-ethnic studies in Hispanic/Latino individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). All eGFR PRSs were highly associated with eGFR (p < 1E-20). Additionally, eGFR PRSs were significantly associated with lower risk of prevalent CKD at visit 1 or 2 and incident CKD at visit 2, with the combined PRSs having the best performance. These PRS findings were replicated in an additional dataset of Hispanic/Latino individuals using data from the Women's Health Initiative SNP Health Association Resource (WHI-SHARe)..

DOI10.1016/j.xhgg.2023.100177
Alternate JournalHGG Adv
PubMed ID36741942
PubMed Central IDPMC9894917
Grant ListUL1 TR000124 / TR / NCATS NIH HHS / United States
HHSN268201300005C / HL / NHLBI NIH HHS / United States
75N92021D00004 / WH / WHI NIH HHS / United States
75N92021D00005 / WH / WHI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
75N92021D00003 / WH / WHI NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
75N92021D00002 / HL / NHLBI NIH HHS / United States
75N92021D00001 / HL / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
MS#: 
1233
Manuscript Lead/Corresponding Author Affiliation: 
Coordinating Center - Collaborative Studies Coordinating Center - UNC at Chapel Hill
ECI: 
Yes
Manuscript Affiliation: 
Coordinating Center - Collaborative Studies Coordinating Center - UNC at Chapel Hill
Manuscript Status: 
Published