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Metabolomic Signatures of Sedentary Behavior and Cardiometabolic Traits in US Hispanics/Latinos: Results from HCHS/SOL.

TitleMetabolomic Signatures of Sedentary Behavior and Cardiometabolic Traits in US Hispanics/Latinos: Results from HCHS/SOL.
Publication TypePublication
Year2023
AuthorsMoon J-Y, Chai JChoul, Yu B, Song RJ, Chen G-C, Graff M, Daviglus ML, Chan Q, Thyagarajan B, Castañeda SF, Grove ML, Cai J, Xue X, Mossavar-Rahmani Y, Vasan RS, Boerwinkle E, Kaplan RC, Qi Q
JournalMed Sci Sports Exerc
Volume55
Issue10
Pagination1781-1791
Date Published2023 Oct 01
ISSN1530-0315
KeywordsAdolescent, Adult, Aged, Cardiovascular Diseases, Diabetes Mellitus, Glycerol, Hispanic or Latino, Humans, Hypertension, Metabolome, Middle Aged, Plasmalogens, Risk Factors, Sedentary Behavior, Young Adult
Abstract

PURPOSE: The aim of this study was to understand the serum metabolomic signatures of moderate-to-vigorous physical activity (MVPA) and sedentary behavior, and further associate their metabolomic signatures with incident cardiometabolic diseases.METHODS: This analysis included 2711 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) aged 18-74 yr (2008-2011). An untargeted, liquid chromatography-mass spectrometry was used to profile the serum metabolome. The associations of metabolites with accelerometer-measured MVPA and sedentary time were examined using survey linear regressions adjusting for covariates. The weighted correlation network analysis identified modules of correlated metabolites in relation to sedentary time, and the modules were associated with incident diabetes, dyslipidemia, and hypertension over the 6-yr follow-up.RESULTS: Of 624 metabolites, 5 and 102 were associated with MVPA and sedentary behavior at false discovery rate (FDR) <0.05, respectively, after adjusting for socioeconomic and lifestyle factors. The weighted correlation network analysis identified 8 modules from 102 metabolites associated with sedentary time. Four modules (branched-chain amino acids, erythritol, polyunsaturated fatty acid, creatine) were positively, and the other four (acyl choline, plasmalogen glycerol phosphatidyl choline, plasmalogen glycerol phosphatidyl ethanolamine, urea cycle) were negatively correlated with sedentary time. Among these modules, a higher branched-chain amino acid score and a lower plasmalogen glycerol phosphatidyl choline score were associated with increased risks of diabetes and dyslipidemia. A higher erythritol score was associated with an increased risk of diabetes, and a lower acyl choline score was linked to an increased risk of hypertension.CONCLUSIONS: In this study of US Hispanics/Latinos, we identified multiple serum metabolomic signatures of sedentary behavior and their associations with risk of incident diabetes, hypertension, and dyslipidemia. These findings suggest a potential role of circulating metabolites in the links between sedentary behavior and cardiometabolic diseases.

DOI10.1249/MSS.0000000000003205
Alternate JournalMed Sci Sports Exerc
PubMed ID37170952
PubMed Central IDPMC10523950
Grant ListHHSN268201300005C / HL / NHLBI NIH HHS / United States
HHSN268201300004C / HL / NHLBI NIH HHS / United States
R01 DK119268 / DK / NIDDK NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
HHSN268201300003C / HG / NHGRI NIH HHS / United States
R01 HL136266 / HL / NHLBI NIH HHS / United States
HHSN268201000001I / HL / NHLBI NIH HHS / United States
HHSN268201300001C / HB / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
MS#: 
0868
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
ECI: 
Yes
Manuscript Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status: 
Published