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Neurocognitive test performance following cancer among middle-aged and older adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and the SOL-Investigation of Neurocognitive Aging Ancillary Study.

TitleNeurocognitive test performance following cancer among middle-aged and older adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and the SOL-Investigation of Neurocognitive Aging Ancillary Study.
Publication TypePublication
Year2023
AuthorsParada H, Pichardo MS, Gallo LC, Talavera GA, McDaniels-Davidson C, Penedo FJ, Lee DJ, Tarraf W, Garcia TP, Daviglus ML, González HM
JournalCancer Med
Volume12
Issue10
Pagination11860-11870
Date Published2023 May
ISSN2045-7634
KeywordsAged, aging, Cognition Disorders, Female, Hispanic or Latino, Humans, Male, Mental Status and Dementia Tests, Middle Aged, Neoplasms, Neuropsychological Tests, Prospective Studies, Prostatic Neoplasms, Self Report, Uterine Cervical Neoplasms
Abstract

BACKGROUND: Cancer patients and survivors often experience acute cognitive impairments; however, the long-term cognitive impact remains unclear particularly among Hispanics/Latinos. We examined the association between cancer history and neurocognitive test performance among middle-aged and older Hispanic/Latinos.METHODS: Participants included 9639 Hispanic/Latino adults from the community-based and prospective Hispanic Community Health Study/Study of Latinos. At baseline (2008-2011; V1), participants self-reported their cancer history. At V1 and again at a 7-year follow-up (2015-2018; V2), trained technicians administered neurocognitive tests including the Brief-Spanish English Verbal Learning Test (B-SEVLT), Word Fluency Test (WF), and Digit Symbol Substitution Test (DSS). We used survey linear regression to estimate the overall, sex-specific, and cancer site-specific [i.e., cervix, breast, uterus, and prostate] adjusted associations between cancer history and neurocognitive test performance at V1 and changes from V1 to V2.RESULTS: At V1, a history of cancer (6.4%) versus no history of cancer (93.6%) was associated with higher WF scores (β = 0.14, SE = 0.06; p = 0.03) and global cognition (β = 0.09, SE = 0.04; p = 0.04). Among women, a history of cervical cancer predicted decreases in SEVLT-Recall scores (β = -0.31, SE = 0.13; p = 0.02) from V1 to V2, and among men, a history of prostate cancer was associated with higher V1 WF scores (β = 0.29, SE = 0.12; p = 0.02) and predicted increases in SEVLT-Sum (β = 0.46, SE = 0.22; p = 0.04) from V1 to V2.CONCLUSION: Among women, a history of cervical cancer was associated with 7-year memory decline, which may reflect the impacts of systemic cancer therapies. Among men, however, a history of prostate cancer was associated with improvements in cognitive performance, perhaps due in part to engaging in health promoting behaviors following cancer.

DOI10.1002/cam4.5863
Alternate JournalCancer Med
PubMed ID36999972
PubMed Central IDPMC10242865
Grant ListR01 AG048642 / AG / NIA NIH HHS / United States
P30 AG062429 / AG / NIA NIH HHS / United States
U54 CA132384 / CA / NCI NIH HHS / United States
R01 AG075758 / AG / NIA NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
P30 AG059299 / AG / NIA NIH HHS / United States
K01 CA234317 / CA / NCI NIH HHS / United States
U54 CA132379 / CA / NCI NIH HHS / United States
R56 AG048642 / AG / NIA NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
MS#: 
1250
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: San Diego (San Diego State University)
ECI: 
Manuscript Affiliation: 
Field Center: San Diego (San Diego State University)
Manuscript Status: 
Published