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The Effect of Self-Reported Visual Impairment and Sleep on Cognitive Decline: Results of the Hispanic Community Health Study/Study of Latinos.

TitleThe Effect of Self-Reported Visual Impairment and Sleep on Cognitive Decline: Results of the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2023
AuthorsMahanna-Gabrielli E, Kuwayama S, Tarraf W, Kaur S, DeBuc DCabrera, Cai J, Daviglus ML, Joslin CE, Lee DJ, Mendoza-Santiesteban C, Stickel AM, Zheng D, González HM, Ramos AR
JournalJ Alzheimers Dis
Volume92
Issue4
Pagination1257-1267
Date Published2023
ISSN1875-8908
KeywordsAged, Cognitive Dysfunction, Hispanic or Latino, Humans, Middle Aged, Self Report, sleep, Sleep Apnea, Obstructive, sleep duration, Sleep Initiation and Maintenance Disorders, Sleepiness, Speech Disorders, Vision Disorders
Abstract

BACKGROUND: Visual impairment could worsen sleep/wake disorders and cognitive decline.OBJECTIVE: To examine interrelations among self-reported visual impairment, sleep, and cognitive decline in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Miami-site.METHOD: HCHS/SOL Miami-site participants ages 45-74 years (n = 665) at Visit-1, who returned for cognitive test 7-years later (SOL-INCA). Participants completed the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ), validated sleep questionnaires and test for obstructive sleep apnea (OSA) at Visit-1. We obtained verbal episodic learning and memory, verbal fluency, processing speed, and executive functioning at Visit-1 and at SOL-INCA. Processing speed/executive functioning were added to SOL-INCA. We examined global cognition and change using a regression-based reliable change index, adjusting for the time lapse between Visit-1 and SOL-INCA. We used regression models to test whether 1) persons with OSA, self-reported sleep duration, insomnia, and sleepiness have an increased risk for visual impairment, 2a) visual impairment is associated with worse cognitive function and/or decline, and 2b) sleep disorders attenuate these associations.RESULT: Sleepiness (β= 0.04; p < 0.01) and insomnia (β= 0.04; p < 0.001) were cross-sectionally associated with visual impairment, adjusting for sociodemographic characteristics, behavioral factors, acculturation, and health conditions. Visual impairment was associated with lower global cognitive function at Visit-1 (β= -0.16; p < 0.001) and on average 7-years later (β= -0.18; p < 0.001). Visual impairment was also associated with a change in verbal fluency (β= -0.17; p < 0.01). OSA, self-reported sleep duration, insomnia, and sleepiness did not attenuate any of the associations.CONCLUSION: Self-reported visual impairment was independently associated with worse cognitive function and decline.

DOI10.3233/JAD-221073
Alternate JournalJ Alzheimers Dis
PubMed ID36872780
PubMed Central IDPMC10792435
Grant ListR01 AG048642 / AG / NIA NIH HHS / United States
R21 HL145425 / HL / NHLBI NIH HHS / United States
R01 HL161012 / HL / NHLBI NIH HHS / United States
R21 AG070644 / AG / NIA NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
P30 AG059299 / AG / NIA NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
P30 AG062429 / AG / NIA NIH HHS / United States
RF1 AG054548 / AG / NIA NIH HHS / United States
RF1 AG061022 / AG / NIA NIH HHS / United States
R35 HL135818 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
R21 AG056952 / AG / NIA NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
R01 AG067568 / AG / NIA NIH HHS / United States
R01 HL153814 / HL / NHLBI NIH HHS / United States
MS#: 
1042
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Miami (University of Miami)
ECI: 
Manuscript Affiliation: 
Field Center: Miami (University of Miami)
Manuscript Status: 
Published