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The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium.

TitleThe Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium.
Publication TypePublication
AuthorsHarville EW, Mishra GD, Yeung E, Mumford SL, Schisterman EF, Jukic AMarie, Hatch EE, Mikkelsen EM, Jiang H, Ehrenthal DB, Porucznik CA, Stanford JB, Wen S-W, Harvey A, Downs DSymons, Yajnik C, Santillan D, Santillan M, McElrath TF, Woo JG, Urbina EM, Chavarro JE, Sotres-Alvarez D, Bazzano L, Zhang J, Steiner A, Gunderson EP, Wise LA
JournalPaediatr Perinat Epidemiol
Date Published2019 Nov
KeywordsAdult, Biomedical Research, Child Health, Female, Humans, Infant Health, Infertility, Intersectoral Collaboration, Male, Maternal Exposure, Paternal Exposure, Preconception Care, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Research Design, Research Support as Topic

BACKGROUND: Preconception health may have intergenerational influences. We have formed the PrePARED (Preconception Period Analysis of Risks and Exposures influencing health and Development) research consortium to address methodological, conceptual, and generalisability gaps in the literature.OBJECTIVES: The consortium will investigate the effects of preconception exposures on four sets of outcomes: (1) fertility and miscarriage; (2) pregnancy-related conditions; (3) perinatal and child health; and (4) adult health outcomes.POPULATION: A study is eligible if it has data measured for at least one preconception time point, has a minimum of selected core data, and is open to collaboration and data harmonisation.DESIGN: The included studies are a mix of studies following women or couples intending to conceive, general-health cohorts that cover the reproductive years, and pregnancy/child cohort studies that have been linked with preconception data. The majority of the participating studies are prospective cohorts, but a few are clinical trials or record linkages.METHODS: Data analysis will begin with harmonisation of data collected across cohorts. Initial areas of interest include nutrition and obesity; tobacco, marijuana, and other substance use; and cardiovascular risk factors.PRELIMINARY RESULTS: Twenty-three cohorts with data on almost 200 000 women have combined to form this consortium, begun in 2018. Twelve studies are of women or couples actively planning pregnancy, and six are general-population cohorts that cover the reproductive years; the remainder have some other design. The primary focus for four was cardiovascular health, eight was fertility, one was environmental exposures, three was child health, and the remainder general women's health. Among other cohorts assessed for inclusion, the most common reason for ineligibility was lack of prospectively collected preconception data.CONCLUSIONS: The consortium will serve as a resource for research in many subject areas related to preconception health, with implications for science, practice, and policy.

Alternate JournalPaediatr Perinat Epidemiol
PubMed ID31659792
PubMed Central IDPMC6901022
Grant ListK23 HD001479 / HD / NICHD NIH HHS / United States
R01 ES020488 / ES / NIEHS NIH HHS / United States
U54 GM104940 / GM / NIGMS NIH HHS / United States
UL1 TR001863 / TR / NCATS NIH HHS / United States
Manuscript Lead/Corresponding Author Affiliation: 
Affiliated Investigator - Not at HCHS/SOL site
Manuscript Affiliation: 
Coordinating Center - Collaborative Studies Coordinating Center - UNC at Chapel Hill
Manuscript Status: 
Published and Public