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Sex Hormones and Diabetes in 45- to 74-year-old Men and Postmenopausal Women: The Hispanic Community Health Study.

TitleSex Hormones and Diabetes in 45- to 74-year-old Men and Postmenopausal Women: The Hispanic Community Health Study.
Publication TypePublication
Year2023
AuthorsPersky V, Abasilim C, Tsintsifas K, Day T, Sargis RM, Daviglus ML, Cai J, Freels S, Unterman T, Chavez N, Kaplan R, Isasi CR, Pirzada A, Meyer ML, Talavera GA, Thyagarajan B, Peters BA, Madrigal JM, Grieco A, Turyk ME
JournalJ Clin Endocrinol Metab
Volume108
Issue7
Pagination1709-1726
Date Published2023 Jun 16
ISSN1945-7197
KeywordsAged, Diabetes Mellitus, Estradiol, Female, glucose, Gonadal Steroid Hormones, Hispanic or Latino, Humans, Male, Middle Aged, Postmenopause, Prediabetic State, Public Health, Sex Hormone-Binding Globulin, Testosterone
Abstract

Previous studies demonstrated associations of endogenous sex hormones with diabetes. Less is known about their dynamic relationship with diabetes progression through different stages of the disease, independence of associations, and role of the hypothalamic-pituitary gonadal axis. The purpose of this analysis was to examine relationships of endogenous sex hormones with incident diabetes, prediabetes, and diabetes traits in 693 postmenopausal women and 1015 men aged 45 to 74 years without diabetes at baseline participating in the Hispanic Community Health Study/Study of Latinos and followed for 6 years. Baseline hormones included estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), and, in men, testosterone and bioavailable testosterone. Associations were analyzed using multivariable Poisson and linear regressions. In men, testosterone was inversely associated with conversion from prediabetes to diabetes (incidence rate ratio [IRR] for 1 SD increase in testosterone: 0.821; 95% CI, 0.676, 0.997; P = 0.046), but not conversion from normoglycemia to prediabetes. Estradiol was positively associated with increase in fasting insulin and homeostatic model assessment of insulin resistance. In women, SHBG was inversely associated with change in glycosylated hemoglobin, postload glucose, and conversion from prediabetes to diabetes (IRR = 0.62; 95% CI, 0.44, 0.86, P = 0.005) but not from normoglycemia to prediabetes. Relationships with other hormones varied across glycemic measures. Stronger associations of testosterone and SHBG with transition from prediabetes to diabetes than from normoglycemic to prediabetes suggest they are operative at later stages of diabetes development. Biologic pathways by which sex hormones affect glucose homeostasis await future studies.

DOI10.1210/clinem/dgad018
Alternate JournalJ Clin Endocrinol Metab
PubMed ID36633580
PubMed Central IDPMC10271226
Grant ListHHSN268201300005C / HL / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
/ NS / NINDS NIH HHS / United States
R01 ES025159 / ES / NIEHS NIH HHS / United States
/ MD / NIMHD NIH HHS / United States
T42 OH008672 / OH / NIOSH CDC HHS / United States
HHSN268201300004C / HL / NHLBI NIH HHS / United States
HHSN268201300001C / HL / NHLBI NIH HHS / United States
/ DE / NIDCR NIH HHS / United States
P30 DK111022 / DK / NIDDK NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
HHSN268201300003C / HL / NHLBI NIH HHS / United States
P30 ES027792 / ES / NIEHS NIH HHS / United States
T42OH008672 / ACL / ACL HHS / United States
P30 DK020595 / DK / NIDDK NIH HHS / United States
MS#: 
600C
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Chicago (University of Illinois at Chicago)
ECI: 
Manuscript Affiliation: 
Field Center: Chicago (University of Illinois at Chicago)
Manuscript Status: 
Published and Public