Title | Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes |
Publication Type | Publication |
Year | 2024 |
Authors | Luo K, Chen G-C, Zhang Y, Moon J-Y, Xing J, Peters BA, Usyk M, Wang Z, Hu G, Li J, Selvin E, Rebholz CM, Wang T, Isasi CR, Yu B, Knight R, Boerwinkle E, Burk RD, Kaplan RC, Qi Q |
Journal | Nat Metab |
Volume | 6 |
Issue | 1 |
Pagination | 169-186 |
Date Published | 2024 Jan |
ISSN | 2522-5812 |
Keywords | Animals, Cattle, Diabetes Mellitus, Type 2, diet, Female, Genotype, Humans, Lactase, Male, Milk |
Abstract | Cow's milk is frequently included in the human diet, but the relationship between milk intake and type 2 diabetes (T2D) remains controversial. Here, using data from the Hispanic Community Health Study/Study of Latinos, we show that in both sexes, higher milk intake is associated with lower risk of T2D in lactase non-persistent (LNP) individuals (determined by a variant of the lactase LCT gene, single nucleotide polymorphism rs4988235 ) but not in lactase persistent individuals. We validate this finding in the UK Biobank. Further analyses reveal that among LNP individuals, higher milk intake is associated with alterations in gut microbiota (for example, enriched Bifidobacterium and reduced Prevotella) and circulating metabolites (for example, increased indolepropionate and reduced branched-chain amino acid metabolites). Many of these metabolites are related to the identified milk-associated bacteria and partially mediate the association between milk intake and T2D in LNP individuals. Our study demonstrates a protective association between milk intake and T2D among LNP individuals and a potential involvement of gut microbiota and blood metabolites in this association. |
DOI | 10.1038/s42255-023-00961-1 |
Alternate Journal | Nat Metab |
PubMed ID | 38253929 |
PubMed Central ID | 6518137 |
Grant List | R01 DK132011 / DK / NIDDK NIH HHS / United States U54 GM104940 / GM / NIGMS NIH HHS / United States |
Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes
MS#:
1127
ECI:
Manuscript Affiliation:
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status:
Published