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Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.

TitleCollaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.
Publication TypePublication
AuthorsOelsner EC, Krishnaswamy A, Balte PP, Allen NBai, Ali T, Anugu P, Andrews HF, Arora K, Asaro A, R Barr G, Bertoni AG, Bon J, Boyle R, Chang AA, Chen G, Coady S, Cole SA, Coresh J, Cornell E, Correa A, Couper D, Cushman M, Demmer RT, Elkind MSV, Folsom AR, Fretts AM, Gabriel KP, Gallo LC, Gutierrez J, Han MLan K, Henderson JM, Howard VJ, Isasi CR, Jacobs DR, Judd SE, Mukaz DKamin, Kanaya AM, Kandula NR, Kaplan RC, Kinney GL, Kucharska-Newton A, Lee JS, Lewis CE, Levine DA, Levitan EB, Levy BD, Make BJ, Malloy K, Manly JJ, Mendoza-Puccini C, Meyer KA, Min Y-INancy, Moll MR, Moore WC, Mauger D, Ortega VE, Palta P, Parker MM, Phipatanakul W, Post WS, Postow L, Psaty BM, Regan EA, Ring K, Roger VL, Rotter JI, Rundek T, Sacco RL, Schembri M, Schwartz DA, Seshadri S, Shikany JM, Sims M, Stukovsky KDHinckley, Talavera GA, Tracy RP, Umans JG, Vasan RS, Watson KE, Wenzel SE, Winters K, Woodruff PG, Xanthakis V, Zhang Y, Zhang Y
Corporate AuthorsC4R Investigators
JournalAm J Epidemiol
Date Published2022 Jun 27
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, COVID-19, Humans, Middle Aged, Pandemics, Prospective Studies, SARS-CoV-2, United States, Young Adult

The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study of adults comprising 14 established US prospective cohort studies. Starting as early as 1971, investigators in the C4R cohort studies have collected data on clinical and subclinical diseases and their risk factors, including behavior, cognition, biomarkers, and social determinants of health. C4R links this pre-coronavirus disease 2019 (COVID-19) phenotyping to information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute and postacute COVID-related illness. C4R is largely population-based, has an age range of 18-108 years, and reflects the racial, ethnic, socioeconomic, and geographic diversity of the United States. C4R ascertains SARS-CoV-2 infection and COVID-19 illness using standardized questionnaires, ascertainment of COVID-related hospitalizations and deaths, and a SARS-CoV-2 serosurvey conducted via dried blood spots. Master protocols leverage existing robust retention rates for telephone and in-person examinations and high-quality event surveillance. Extensive prepandemic data minimize referral, survival, and recall bias. Data are harmonized with research-quality phenotyping unmatched by clinical and survey-based studies; these data will be pooled and shared widely to expedite collaboration and scientific findings. This resource will allow evaluation of risk and resilience factors for COVID-19 severity and outcomes, including postacute sequelae, and assessment of the social and behavioral impact of the pandemic on long-term health trajectories.

Alternate JournalAm J Epidemiol
PubMed ID35279711
PubMed Central IDPMC8992336
Grant ListR01 HL093009 / HL / NHLBI NIH HHS / United States
R21 HL153700 / HL / NHLBI NIH HHS / United States
K24 HL112827 / HL / NHLBI NIH HHS / United States
R21 HL129924 / HL / NHLBI NIH HHS / United States
K23 HL130627 / HL / NHLBI NIH HHS / United States
P50 HD105352 / HD / NICHD NIH HHS / United States
UL1 TR001872 / TR / NCATS NIH HHS / United States
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Baseline Visit - Pulmonary Reading Center - Columbia University
Manuscript Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status: 
Published and Public