Accessibility issues or difficulties with this website?
Call 919-962-2073 or email hchsadministration@unc.edu.

Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population.

TitleObstructive sleep apnea and neurocognitive function in a Hispanic/Latino population.
Publication TypePublication
Year2015
AuthorsRamos AR, Tarraf W, Rundek T, Redline S, Wohlgemuth WK, Loredo JS, Sacco RL, Lee DJ, Arens R, Lazalde P, Choca JP, Mosley T, González HM
JournalNeurology
Volume84
Issue4
Pagination391-8
Date Published2015 Jan 27
ISSN1526-632X
KeywordsAged, Cognition Disorders, Female, Hispanic Americans, Humans, Male, Middle Aged, Neuropsychological Tests, Sex Factors, Sleep Apnea, Obstructive, United States
Abstract

OBJECTIVE: We evaluated the association between obstructive sleep apnea (OSA) and neurocognitive function among community-dwelling Hispanic/Latino individuals in the United States.METHODS: Cross-sectional analysis of the Hispanic Community Health Study/Study of Latinos middle-aged and older adults, aged 45 to 74 years, with neurocognitive test scores at baseline measurements from 2008 to 2011. Neurocognitive scores were measured using the Word Fluency (WF) Test, the Brief-Spanish English Verbal Learning Test (SEVLT), and the Digit Symbol Substitution (DSS) Test. OSA was defined by the apnea-hypopnea index (AHI). Multivariable linear regression models were fit to evaluate relations between OSA and neurocognitive scores.RESULTS: The analysis consisted of 8,059 participants, mean age of 56 years, 55% women, and 41% with less than high school education. The mean AHI was 9.0 (range 0-142; normal AHI <5/h). There was an association between the AHI and all 4 neurocognitive test scores: Brief-SEVLT-sum (β = -0.022) and -recall (β = -0.010), WF (β = -0.023), and DSS (β = -0.050) at p < 0.01 that was fully attenuated by age. In the fully adjusted regression model, female sex was a moderating factor between the AHI and WF (β = -0.027, p < 0.10), SVELT-sum (β = -0.37), SVELT-recall (β = -0.010), and DSS (β = -0.061) at p < 0.01.CONCLUSION: OSA was associated with worse neurocognitive function in a representative sample of Hispanic/Latino women in the United States.

DOI10.1212/WNL.0000000000001181
Alternate JournalNeurology
PubMed ID25540308
PubMed Central IDPMC4336004
Grant ListKL2 TR000461 / TR / NCATS NIH HHS / United States
N01-HC65237 / HC / NHLBI NIH HHS / United States
N01-HC65233 / HC / NHLBI NIH HHS / United States
N01-HC65234 / HC / NHLBI NIH HHS / United States
N01-HC65236 / HC / NHLBI NIH HHS / United States
N01-HC65235 / HC / NHLBI NIH HHS / United States
1KL2TR000461 / TR / NCATS NIH HHS / United States
MS#: 
0044
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Miami (University of Miami)
ECI: 
Yes
Manuscript Status: 
Published