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Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos.

TitleSmoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2016
AuthorsFranceschini N, Deng Y, Flessner MF, Eckfeldt JH, Kramer HJ, Lash JP, Lee DJ, Melamed ML, Moncrieft AE, Ricardo AC, Rosas SE, Kaplan RC, Raij L, Cai J
JournalNephrol Dial Transplant
Volume31
Issue10
Pagination1670-6
Date Published2016 10
ISSN1460-2385
KeywordsAdolescent, Adult, Aged, Cross-Sectional Studies, Female, Hispanic Americans, Humans, Male, Middle Aged, Odds Ratio, Prevalence, Renal Insufficiency, Chronic, Risk Factors, Smoking, Surveys and Questionnaires, United States, Young Adult
Abstract

BACKGROUND: Intermittent smoking is prevalent among Hispanics, but little is known about whether this smoking pattern associates with increased chronic kidney disease (CKD) risk in this population. The objective of the present study is to identify patterns of exposure associated with CKD in US Hispanics.METHODS: We used cross-sectional data on 15 410 participants of the Hispanics Community Health Study/the Study of Latinos, a population-based study of individuals aged 18-74 years, recruited in 2008 to 2011 from four US field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). Smoking exposure was obtained through a questionnaire. CKD was defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m(2) or a urine albumin-to-creatinine ratio of ≥30 mg/g.RESULTS: Approximately 14% of individuals were daily and 7% were intermittent smokers, and 16% were past smokers. There was a significant interaction between smoking status and pack-years of exposure (P = 0.0003). In adjusted models, there was an increased odds of CKD among daily, intermittent and past smokers by pack-years compared with never smokers. The association of intermittent smokers was significant at 10 pack-years [odds ratio (OR) = 1.38, 95% confidence intervals (CI) 1.06, 1.81], whereas for daily smokers this association was observed at 40 pack-years (OR = 1.43, 95% CI 1.09, 1.89).CONCLUSIONS: Our findings of increased risk of CKD among Hispanics who are intermittent smokers support screening and smoking cessation interventions targeted to this population for the prevention of CKD. It also suggests novel mechanistic pathways for kidney toxicity that should be further explored in future studies.

DOI10.1093/ndt/gfw210
Alternate JournalNephrol Dial Transplant
PubMed ID27257272
PubMed Central IDPMC5039342
Grant ListK24 DK092290 / DK / NIDDK NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
R21 HL123677 / HL / NHLBI NIH HHS / United States
K23 DK094829 / DK / NIDDK NIH HHS / United States
MS#: 
0226
Manuscript Lead/Corresponding Author Affiliation: 
Coordinating Center - Collaborative Studies Coordinating Center - UNC at Chapel Hill
ECI: 
Manuscript Affiliation: 
Coordinating Center - Collaborative Studies Coordinating Center - UNC at Chapel Hill
Manuscript Status: 
Published