|Title||Detecting prediabetes among Hispanics/Latinos from diverse heritage groups: Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos.|
|Authors||M Avilés-Santa L, Pérez CM, Schneiderman N, Savage PJ, Kaplan RC, Teng Y, Suárez EL, Cai J, Giachello AL, Talavera GA, Cowie CC|
|Date Published||2017 02|
|Keywords||Cross-Sectional Studies, Culture, Diabetes Mellitus, Type 2, Glucose Tolerance Test, Glycated Hemoglobin A, Hispanic Americans, Humans, Hypertension, Prediabetic State, Prevalence, Risk Factors, Surveys and Questionnaires|
The objectives of this analysis were to compare the ability of fasting plasma glucose (FPG), post oral load plasma glucose (2hPG), and hemoglobin A (HbA) to identify U.S. Hispanic/Latino individuals with prediabetes, and to assess its cardiovascular risk factor correlates. This is a cross-sectional analysis of baseline data from 15,507 adults without self-reported diabetes mellitus from six Hispanic/Latino heritage groups, enrolled in the Hispanic Community Health Study/Study of Latinos, which takes place in four U.S. communities. The prevalence of prediabetes was determined according to individual or combinations of ADA-defined cut points: FPG=5.6-7.0mmol/L, 2hPG=7.8-11.1mmol/L, and HbA=5.7%-6.4% (39-46mmol/mol). The sensitivity of these criteria to detect prediabetes was estimated. The prevalence ratios (PRs) for selected cardiovascular risk factors were compared among alternative categories of prediabetes versus normoglycemia [FPG<5.6mmol/L and 2hPG<7.8mmol/L and HbA<5.7% (39mmol/mol)]. Approximately 36% of individuals met any of the ADA prediabetes criteria. Using 2hPG as the gold standard, the sensitivity of FPG was 40.1%, HbA was 45.6%, and that of HbA+FPG was 62.2%. The number of significant PRs for cardiovascular risk factors was higher among individuals with isolated 2hPG=7.8-11.1mmol/L, FPG=5.6-7.0mmol/L+HbA=5.7%-6.4%, or those who met the three prediabetes criteria. Assessing FPG, HbA, and cardiovascular risk factors in Hispanics/Latinos at risk might enhance the early prevention of diabetes mellitus and cardiovascular complications in this young and growing population, independent of their heritage group.
|Alternate Journal||Prev Med|
|PubMed Central ID||PMC5290333|
|Grant List||N01HC65236 / HL / NHLBI NIH HHS / United States |
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
Z99 HL999999 / / Intramural NIH HHS / United States
Detecting prediabetes among Hispanics/Latinos from diverse heritage groups: Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos.
NHLBI - National Heart, Lung, and Blood Institute (NHLBI is the lead NIH sponsor & Project Office for HCHS)