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Detecting prediabetes among Hispanics/Latinos from diverse heritage groups: Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos.

TitleDetecting prediabetes among Hispanics/Latinos from diverse heritage groups: Does the test matter? Findings from the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2017
AuthorsM Avilés-Santa L, Pérez CM, Schneiderman N, Savage PJ, Kaplan RC, Teng Y, Suárez EL, Cai J, Giachello AL, Talavera GA, Cowie CC
JournalPrev Med
Volume95
Pagination110-118
Date Published2017 02
ISSN1096-0260
KeywordsCross-Sectional Studies, Culture, Diabetes Mellitus, Type 2, Glucose Tolerance Test, Glycated Hemoglobin A, Hispanic Americans, Humans, Hypertension, Prediabetic State, Prevalence, Risk Factors, Surveys and Questionnaires
Abstract

The objectives of this analysis were to compare the ability of fasting plasma glucose (FPG), post oral load plasma glucose (2hPG), and hemoglobin A (HbA) to identify U.S. Hispanic/Latino individuals with prediabetes, and to assess its cardiovascular risk factor correlates. This is a cross-sectional analysis of baseline data from 15,507 adults without self-reported diabetes mellitus from six Hispanic/Latino heritage groups, enrolled in the Hispanic Community Health Study/Study of Latinos, which takes place in four U.S. communities. The prevalence of prediabetes was determined according to individual or combinations of ADA-defined cut points: FPG=5.6-7.0mmol/L, 2hPG=7.8-11.1mmol/L, and HbA=5.7%-6.4% (39-46mmol/mol). The sensitivity of these criteria to detect prediabetes was estimated. The prevalence ratios (PRs) for selected cardiovascular risk factors were compared among alternative categories of prediabetes versus normoglycemia [FPG<5.6mmol/L and 2hPG<7.8mmol/L and HbA<5.7% (39mmol/mol)]. Approximately 36% of individuals met any of the ADA prediabetes criteria. Using 2hPG as the gold standard, the sensitivity of FPG was 40.1%, HbA was 45.6%, and that of HbA+FPG was 62.2%. The number of significant PRs for cardiovascular risk factors was higher among individuals with isolated 2hPG=7.8-11.1mmol/L, FPG=5.6-7.0mmol/L+HbA=5.7%-6.4%, or those who met the three prediabetes criteria. Assessing FPG, HbA, and cardiovascular risk factors in Hispanics/Latinos at risk might enhance the early prevention of diabetes mellitus and cardiovascular complications in this young and growing population, independent of their heritage group.

DOI10.1016/j.ypmed.2016.12.009
Alternate JournalPrev Med
PubMed ID27956225
PubMed Central IDPMC5290333
Grant ListN01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
Z99 HL999999 / / Intramural NIH HHS / United States
MS#: 
0024
Manuscript Lead/Corresponding Author Affiliation: 
NHLBI - National Heart, Lung, and Blood Institute (NHLBI is the lead NIH sponsor & Project Office for HCHS)
ECI: 
Manuscript Affiliation: 
NHLBI - National Heart, Lung, and Blood Institute (NHLBI is the lead NIH sponsor & Project Office for HCHS)
Manuscript Status: 
Published