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Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

TitleGenetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Publication TypePublication
Year2017
AuthorsQi Q, Stilp AM, Sofer T, Moon J-Y, Hidalgo B, Szpiro AA, Wang T, C Y Ng M, Guo X, Chen Y-DIda, Taylor KD, M Avilés-Santa L, Papanicolaou G, Pankow JS, Schneiderman N, Laurie CC, Rotter JI, Kaplan RC
Corporate AuthorsMEta-analysis of type 2 DIabetes in African Americans(MEDIA) Consortium
JournalDiabetes
Volume66
Issue5
Pagination1419-1425
Date Published2017 05
ISSN1939-327X
KeywordsAdolescent, Adult, African Americans, Aged, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, genome-wide association study, Genotype, Genotyping Techniques, Haplotypes, Hispanic Americans, Humans, KCNQ1 Potassium Channel, Linear Models, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Risk Assessment, Transcription Factor 7-Like 2 Protein, United States, Young Adult
Abstract

Few genome-wide association studies (GWAS) of type 2 diabetes (T2D) have been conducted in U.S. Hispanics/Latinos of diverse backgrounds who are disproportionately affected by diabetes. We conducted a GWAS in 2,499 T2D case subjects and 5,247 control subjects from six Hispanic/Latino background groups in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Our GWAS identified two known loci ( and reaching genome-wide significance levels. Conditional analysis on known index single nucleotide polymorphisms (SNPs) indicated an additional independent signal at , represented by an African ancestry-specific variant, rs1049549 (odds ratio 1.49 [95% CI 1.27-1.75]). This association was consistent across Hispanic/Latino background groups and replicated in the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium. Among 80 previously known index SNPs at T2D loci, 66 SNPs showed consistency with the reported direction of associations and 14 SNPs significantly generalized to the HCHS/SOL. A genetic risk score based on these 80 index SNPs was significantly associated with T2D (odds ratio 1.07 [1.06-1.09] per risk allele), with a stronger effect observed in nonobese than in obese individuals. Our study identified a novel independent signal suggesting an African ancestry-specific allele at for T2D. Associations between previously identified loci and T2D were generally shown in a large cohort of U.S. Hispanics/Latinos.

DOI10.2337/db16-1150
Alternate JournalDiabetes
PubMed ID28254843
PubMed Central IDPMC5399610
Grant ListUL1 TR000124 / TR / NCATS NIH HHS / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
K01 HL130609 / HL / NHLBI NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
K01 HL129892 / HL / NHLBI NIH HHS / United States
MS#: 
0323
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
ECI: 
Yes
Manuscript Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
Manuscript Status: 
Published