|Title||Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).|
|Authors||Qi Q, Stilp AM, Sofer T, Moon J-Y, Hidalgo B, Szpiro AA, Wang T, C Y Ng M, Guo X, Chen Y-DIda, Taylor KD, M Avilés-Santa L, Papanicolaou G, Pankow JS, Schneiderman N, Laurie CC, Rotter JI, Kaplan RC|
|Corporate Authors||MEta-analysis of type 2 DIabetes in African Americans(MEDIA) Consortium|
|Date Published||2017 05|
|Keywords||Adolescent, Adult, African Americans, Aged, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, genome-wide association study, Genotype, Genotyping Techniques, Haplotypes, Hispanic or Latino, Humans, KCNQ1 Potassium Channel, Linear Models, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Risk Assessment, Transcription Factor 7-Like 2 Protein, United States, Young Adult|
Few genome-wide association studies (GWAS) of type 2 diabetes (T2D) have been conducted in U.S. Hispanics/Latinos of diverse backgrounds who are disproportionately affected by diabetes. We conducted a GWAS in 2,499 T2D case subjects and 5,247 control subjects from six Hispanic/Latino background groups in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Our GWAS identified two known loci ( and reaching genome-wide significance levels. Conditional analysis on known index single nucleotide polymorphisms (SNPs) indicated an additional independent signal at , represented by an African ancestry-specific variant, rs1049549 (odds ratio 1.49 [95% CI 1.27-1.75]). This association was consistent across Hispanic/Latino background groups and replicated in the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium. Among 80 previously known index SNPs at T2D loci, 66 SNPs showed consistency with the reported direction of associations and 14 SNPs significantly generalized to the HCHS/SOL. A genetic risk score based on these 80 index SNPs was significantly associated with T2D (odds ratio 1.07 [1.06-1.09] per risk allele), with a stronger effect observed in nonobese than in obese individuals. Our study identified a novel independent signal suggesting an African ancestry-specific allele at for T2D. Associations between previously identified loci and T2D were generally shown in a large cohort of U.S. Hispanics/Latinos.
|PubMed Central ID||PMC5399610|
|Grant List||UL1 TR000124 / TR / NCATS NIH HHS / United States |
P30 DK020541 / DK / NIDDK NIH HHS / United States
K01 HL130609 / HL / NHLBI NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
K01 HL129892 / HL / NHLBI NIH HHS / United States
Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Field Center: Bronx (Einstein College of Medicine)