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A meta-analysis of genome-wide association studies of asthma in Puerto Ricans.

TitleA meta-analysis of genome-wide association studies of asthma in Puerto Ricans.
Publication TypePublication
Year2017
AuthorsYan Q, Brehm J, Pino-Yanes M, Forno E, Lin J, Oh SS, Acosta-Perez E, Laurie CC, Cloutier MM, Raby BA, Stilp AM, Sofer T, Hu D, Huntsman S, Eng CS, Conomos MP, Rastogi D, Rice K, Canino G, Chen W, R Barr G, Burchard EG, Celedón JC
JournalEur Respir J
Volume49
Issue5
Date Published2017 05
ISSN1399-3003
KeywordsAdolescent, Adult, asthma, Child, Chromosomes, Human, Pair 17, Female, Genetic Predisposition to Disease, genome-wide association study, Hispanic Americans, Humans, Linkage Disequilibrium, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Puerto Rico, Young Adult
Abstract

Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans.We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford-Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10) at Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as (, and ) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans, we replicated findings for rs2305480 at , but not for SNPs in any other genes. On the other hand, we replicated results from a meta-analysis of North American populations for SNPs at , and but not for Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans.

DOI10.1183/13993003.01505-2016
Alternate JournalEur Respir J
PubMed ID28461288
PubMed Central IDPMC5527708
Grant ListN01 HC065234 / HC / NHLBI NIH HHS / United States
R01 ES015794 / ES / NIEHS NIH HHS / United States
HHSN268201300005C / HL / NHLBI NIH HHS / United States
K08 HL125666 / HL / NHLBI NIH HHS / United States
K23 HL004464 / HL / NHLBI NIH HHS / United States
R01 HL117191 / HL / NHLBI NIH HHS / United States
K23 HL118733 / HL / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01 HC065237 / HC / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01 HC065233 / HC / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
T32 GM007546 / GM / NIGMS NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
N01 HC065236 / HC / NHLBI NIH HHS / United States
R01 HL117004 / HL / NHLBI NIH HHS / United States
P60 MD006902 / MD / NIMHD NIH HHS / United States
N01 HC065235 / HC / NHLBI NIH HHS / United States
R01 HL079966 / HL / NHLBI NIH HHS / United States
R21 ES024844 / ES / NIEHS NIH HHS / United States
R01 HL088133 / HL / NHLBI NIH HHS / United States
MS#: 
0300
Manuscript Lead/Corresponding Author Affiliation: 
Affiliated Investigator - Not at HCHS/SOL site
ECI: 
Manuscript Status: 
Published