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Prolonged, Uninterrupted Sedentary Behavior and Glycemic Biomarkers Among US Hispanic/Latino Adults: The HCHS/SOL (Hispanic Community Health Study/Study of Latinos).

TitleProlonged, Uninterrupted Sedentary Behavior and Glycemic Biomarkers Among US Hispanic/Latino Adults: The HCHS/SOL (Hispanic Community Health Study/Study of Latinos).
Publication TypePublication
Year2017
AuthorsDiaz KM, Goldsmith J, Greenlee H, Strizich G, Qi Q, Mossavar-Rahmani Y, Vidot DC, Buelna C, Brintz CE, Elfassy T, Gallo LC, Daviglus ML, Sotres-Alvarez D, Kaplan RC
JournalCirculation
Volume136
Issue15
Pagination1362-1373
Date Published2017 Oct 10
ISSN1524-4539
KeywordsAdolescent, Adult, Aged, Biomarkers, Blood Glucose, Female, Glycated Hemoglobin A, Hispanic Americans, Humans, insulin resistance, Longitudinal Studies, Male, Middle Aged, Models, Biological, Sedentary Behavior
Abstract

BACKGROUND: Excessive sedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Few studies have examined whether the manner in which sedentary time is accrued (in short or long bouts) carries any clinical relevance. The purpose of this study was to examine the association of prolonged, uninterrupted sedentary behavior with glycemic biomarkers in a cohort of US Hispanic/Latino adults.METHODS: We studied 12 083 participants from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos), a population-based study of Hispanic/Latino adults 18 to 74 years of age. Homeostatic model assessment of insulin resistance and glycosylated hemoglobin were measured from a fasting blood sample, and 2-hour glucose was measured after an oral glucose tolerance test. Sedentary time was objectively measured with a hip-mounted accelerometer. Prolonged, uninterrupted sedentariness was expressed as mean sedentary bout length.RESULTS: After adjustment for potential confounders and moderate to vigorous physical activity, longer sedentary bout duration was dose-dependently associated with increased homeostatic model assessment of insulin resistance ( for trend<0.001) and 2-hour glucose levels ( for trend=0.015). These associations were not independent of total sedentary time; however, a significant interaction between sedentary bout duration and total sedentary time was observed. Evaluation of the joint association of total sedentary time and sedentary bout duration showed that participants in the upper quartile for both sedentary characteristics (ie, high total sedentary time and high sedentary bout duration) had the highest levels of homeostatic model assessment of insulin resistance (<0.001 versus low group for both sedentary characteristics) and 2-hour glucose (=0.002 versus low group for both sedentary characteristics). High total sedentary time or high sedentary bout duration alone were not associated with differences in any glycemic biomarkers.CONCLUSIONS: Accruing sedentary time in prolonged, uninterrupted bouts may be deleteriously associated with biomarkers of glucose regulation.

DOI10.1161/CIRCULATIONAHA.116.026858
Alternate JournalCirculation
PubMed ID28835368
PubMed Central IDPMC5634934
Grant ListN01 HC065234 / HC / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01 HC065237 / HC / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
K01 HL129892 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
R01 HL116470 / HL / NHLBI NIH HHS / United States
N01 HC065236 / HC / NHLBI NIH HHS / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
N01 HC065235 / HC / NHLBI NIH HHS / United States
R01 HL136266 / HL / NHLBI NIH HHS / United States
MS#: 
0390
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Bronx (Einstein College of Medicine)
ECI: 
Manuscript Status: 
Published