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Ankle brachial index and cognitive function among Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos.

TitleAnkle brachial index and cognitive function among Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos.
Publication TypePublication
Year2018
AuthorsTarraf W, Criqui MH, Allison MA, Wright CB, Fornage M, Daviglus M, Kaplan RC, Davis S, Conceicao AS, González HM
JournalAtherosclerosis
Volume271
Pagination61-69
Date Published2018 04
ISSN1879-1484
KeywordsAdolescent, Adult, Aged, ankle brachial index, Cognition, Cognition Disorders, Cross-Sectional Studies, executive function, Female, Hispanic Americans, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Peripheral Arterial Disease, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, United States, Vascular Stiffness, Verbal Behavior, Young Adult
Abstract

BACKGROUND AND AIMS: The Ankle-Brachial index (ABI) is a well-accepted measure of peripheral artery disease (arterial stenosis and stiffness) and has been shown to be associated with cognitive function and disorders; however, these associations have not been examined in Hispanics/Latinos. Therefore, we sought to examine relationships between ABI and cognitive function among diverse middle-age and older Hispanics/Latinos.METHODS: We used cross-sectional data on n = 7991 participants aged 45-74 years, without stroke or coronary heart disease, from the Hispanic Community Health Study/Study of Latinos. Our primary outcome, global cognition (GC), was a continuous composite score of four cognitive domains (verbal learning and memory, verbal fluency, executive function, and mental status). Secondary outcomes were the individual tests representing these domains. The ABI was analyzed continuously and categorically with standard clinical cut-points. We tested associations using generalized survey regression models incrementally adjusting for confounding factors. Age, sex, hypertension, diabetes, and dyslipidemia moderations were examined through interactions with the primary exposure.RESULTS: In age, sex, and education adjusted models, continuous ABI had an inverse u-shape association with worse GC. We found similar associations with measures of verbal learning and memory, verbal fluency, executive function, but not with low mental status. The associations were attenuated, but not completely explained, by accounting for the confounders and not modified by age, sex, education, and vascular disease risks.CONCLUSIONS: In addition to being a robust indicator of arterial compromise, our study suggests that abnormal ABI readings may also be useful for early signaling of subtle cognitive deficits.

DOI10.1016/j.atherosclerosis.2018.02.016
Alternate JournalAtherosclerosis
PubMed ID29459267
PubMed Central IDPMC6467470
Grant ListP30 AG053760 / AG / NIA NIH HHS / United States
P50 AG005131 / AG / NIA NIH HHS / United States
R01 AG048642 / AG / NIA NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
MS#: 
0435
Manuscript Lead/Corresponding Author Affiliation: 
HCHS/SOL Baseline Visit - Neurocognitive Reading Center
ECI: 
Manuscript Status: 
Published