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Relation of Diabetes to Cognitive Function in Hispanics/Latinos of Diverse Backgrounds in the United States.

TitleRelation of Diabetes to Cognitive Function in Hispanics/Latinos of Diverse Backgrounds in the United States.
Publication TypePublication
Year2019
AuthorsElfassy T, Aiello AE, Schneiderman N, Haan MN, Tarraf W, González HM, Gellman M, Florez HJ, Luchsinger JA, Wright CB, Grober E, Hazzouri AZeki Al
JournalJ Aging Health
Volume31
Issue7
Pagination1155-1171
Date Published2019 08
ISSN1552-6887
KeywordsAdult, Aged, Cognition, Cross-Sectional Studies, Diabetes Mellitus, Female, Hispanic Americans, Humans, Male, Mexico, Middle Aged, Prevalence, Risk Factors, South America, United States, West Indies
Abstract

To examine the association between diabetes and cognitive function within U.S. Hispanics/Latinos of Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American background. This cross-sectional study included 9,609 men and women (mean age = 56.5 years), who are members of the Hispanic Community Health Study/Study of Latinos. We classified participants as having diabetes, prediabetes, or normal glucose regulation. Participants underwent a neurocognitive battery consisting of tests of verbal fluency, delayed recall, and processing speed. Analyses were stratified by Hispanic/Latino subgroup. From fully adjusted linear regression models, compared with having normal glucose regulation, having diabetes was associated with worse processing speed among Cubans (β = -1.99; 95% CI [confidence interval] = [-3.80, -0.19]) and Mexicans (β = -2.26; 95% CI = [-4.02, -0.51]). Compared with having normal glucose regulation, having prediabetes or diabetes was associated with worse delayed recall only among Mexicans (prediabetes: β = -0.34; 95% CI = [-0.63, -0.05] and diabetes: β = -0.41; 95% CI = [-0.79, -0.04]). No associations with verbal fluency. The relationship between diabetes and cognitive function varied across Hispanic/Latino subgroup.

DOI10.1177/0898264318759379
Alternate JournalJ Aging Health
PubMed ID29577792
PubMed Central IDPMC7020246
Grant ListN01 HC065234 / HC / NHLBI NIH HHS / United States
KL2 TR002737 / TR / NCATS NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
K01 AG047273 / AG / NIA NIH HHS / United States
R01 DK087864 / DK / NIDDK NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
P30 DK111022 / DK / NIDDK NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
K24 AG045334 / AG / NIA NIH HHS / United States
T32 HL007426 / HL / NHLBI NIH HHS / United States
MS#: 
0329
Manuscript Lead/Corresponding Author Affiliation: 
Field Center: Miami (University of Miami)
ECI: 
Yes
Manuscript Status: 
Published